Microarrays have revolutionized molecular biology and medicine, with thollsands of hybridizations run and aliknown messengers of an organism studied togethel; instead of one gene and one messenger at a time. Major applicationsof microarray technology so far proposed refer to: a) genotyping, i.e. the definition of a specific genotype bydirect detection of known mutations/polymorphisms; b) gene expression and discovery, i.e. in order to simply answer the following question «which genes are expressed and to what extent ?» Specific applications include: a) predicting gene function, on the basis of specific expression patterns; b) linking celi pathways; c) «fingerprinting» of cellular or disease phenotype; d) drug discovery and drug target validation.At the present review we will give attempt to update the reader on the possible and practical use of microarraytechnology in clinical practice.
MICROCHIPS AND CLINICAL PRACTICE / P., Gasparini; Paolucci, Paolo. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - STAMPA. - 29:1(2003), pp. 12-17.
MICROCHIPS AND CLINICAL PRACTICE.
PAOLUCCI, Paolo
2003
Abstract
Microarrays have revolutionized molecular biology and medicine, with thollsands of hybridizations run and aliknown messengers of an organism studied togethel; instead of one gene and one messenger at a time. Major applicationsof microarray technology so far proposed refer to: a) genotyping, i.e. the definition of a specific genotype bydirect detection of known mutations/polymorphisms; b) gene expression and discovery, i.e. in order to simply answer the following question «which genes are expressed and to what extent ?» Specific applications include: a) predicting gene function, on the basis of specific expression patterns; b) linking celi pathways; c) «fingerprinting» of cellular or disease phenotype; d) drug discovery and drug target validation.At the present review we will give attempt to update the reader on the possible and practical use of microarraytechnology in clinical practice.Pubblicazioni consigliate
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