The aim of this work was to evaluate the synergybetween di¡erent lightening agents when associated;depigmenting activity was tested in vitro bymonitoring the appearance of dopachrome, an intermediatein the melanogenesis process. The resultsobtained were compared with the depigmentingactivity of each single compound, keeping the sameglobal concentration of inhibitor.Our studies showed that the combinationof hydroquinoneand kojic acid had a synergistic e¡ect, andthat the maximum inhibiting action was achievedwith an equimolecular mixture. This result couldserve inthe cosmetics ¢eld to prepare skin-lighteningformulations that are less irritant.We also investigated the feasibility of complexinghydroquinone with cyclodextrin and evaluated thee¡ectiveness of the complex obtained in the treatmentof hyperpigmentation.
New combined treatment of hypermelanosis: analytical studies on efficacy and stability improvement / Ferioli, Valeria; Rustichelli, Cecilia; Pavesi, G.; Gamberini, G.. - In: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. - ISSN 0142-5463. - ELETTRONICO. - 23:6(2001), pp. 333-340. [10.1046/j.1467-2494.2001.00099.x]
New combined treatment of hypermelanosis: analytical studies on efficacy and stability improvement
FERIOLI, Valeria;RUSTICHELLI, Cecilia;
2001
Abstract
The aim of this work was to evaluate the synergybetween di¡erent lightening agents when associated;depigmenting activity was tested in vitro bymonitoring the appearance of dopachrome, an intermediatein the melanogenesis process. The resultsobtained were compared with the depigmentingactivity of each single compound, keeping the sameglobal concentration of inhibitor.Our studies showed that the combinationof hydroquinoneand kojic acid had a synergistic e¡ect, andthat the maximum inhibiting action was achievedwith an equimolecular mixture. This result couldserve inthe cosmetics ¢eld to prepare skin-lighteningformulations that are less irritant.We also investigated the feasibility of complexinghydroquinone with cyclodextrin and evaluated thee¡ectiveness of the complex obtained in the treatmentof hyperpigmentation.
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