The aim of this study was twofold: to assess the rela-tionship between c-Myb and Bcl-x expression and toevaluate the prognostic significance of their expres-sion in colorectal carcinoma (CRC) patients. Analysisof tumors from 91 CRC patients for expression ofc-Myb and Bcl-x revealed a significant relationshipbetween these two proteins. Kaplan-Meier’s analysisshowed an increased risk of relapse and death inpatients whose tumor specimens displayed highc-Myb levels and Bcl-x positivity. Similar results werealso observed excluding Dukes’ D patients. Molecularanalysis using three c-Myb-overexpressing LoVoclones indicated that c-Myb overexpression was ac-companied by up-regulation of Bcl-xL protein andmRNA. Tumors originating from these clones injectedin nude mice were significantly larger than thoseformed in mice injected with parental or vector-trans-fected LoVo cells. Moreover , tumors derived from pa-rental and control vector-transfected but not fromc-Myb-overexpressing LoVo cells showed high fre-quency of apoptotic cells. These results provide directevidence of an association between c-Myb and Bcl-xexpression and suggest that expression of both mol-ecules might be a useful prognostic marker in CRC.

C-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: Clinical and experimental findings / Biroccio, A.; Benassi, B.; D`agnano, I.; D`angelo, C.; Buglioni, S.; Mottolese, M.; Ricciotti, A.; Citro, G.; Cosimelli, M.; Ramsay, R. G.; Calabretta, Bruno; Zupi, G.. - In: THE AMERICAN JOURNAL OF PATHOLOGY. - ISSN 0002-9440. - STAMPA. - 158:4(2001), pp. 1289-1299. [10.1016/S0002-9440(10)64080-1]

C-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: Clinical and experimental findings

CALABRETTA, Bruno;
2001

Abstract

The aim of this study was twofold: to assess the rela-tionship between c-Myb and Bcl-x expression and toevaluate the prognostic significance of their expres-sion in colorectal carcinoma (CRC) patients. Analysisof tumors from 91 CRC patients for expression ofc-Myb and Bcl-x revealed a significant relationshipbetween these two proteins. Kaplan-Meier’s analysisshowed an increased risk of relapse and death inpatients whose tumor specimens displayed highc-Myb levels and Bcl-x positivity. Similar results werealso observed excluding Dukes’ D patients. Molecularanalysis using three c-Myb-overexpressing LoVoclones indicated that c-Myb overexpression was ac-companied by up-regulation of Bcl-xL protein andmRNA. Tumors originating from these clones injectedin nude mice were significantly larger than thoseformed in mice injected with parental or vector-trans-fected LoVo cells. Moreover , tumors derived from pa-rental and control vector-transfected but not fromc-Myb-overexpressing LoVo cells showed high fre-quency of apoptotic cells. These results provide directevidence of an association between c-Myb and Bcl-xexpression and suggest that expression of both mol-ecules might be a useful prognostic marker in CRC.
2001
158
4
1289
1299
C-Myb and Bcl-x overexpression predicts poor prognosis in colorectal cancer: Clinical and experimental findings / Biroccio, A.; Benassi, B.; D`agnano, I.; D`angelo, C.; Buglioni, S.; Mottolese, M.; Ricciotti, A.; Citro, G.; Cosimelli, M.; Ramsay, R. G.; Calabretta, Bruno; Zupi, G.. - In: THE AMERICAN JOURNAL OF PATHOLOGY. - ISSN 0002-9440. - STAMPA. - 158:4(2001), pp. 1289-1299. [10.1016/S0002-9440(10)64080-1]
Biroccio, A.; Benassi, B.; D`agnano, I.; D`angelo, C.; Buglioni, S.; Mottolese, M.; Ricciotti, A.; Citro, G.; Cosimelli, M.; Ramsay, R. G.; Calabretta...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/14263
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