We evaluated a Biochip™-based immunofluorescence assay for improved diagnosis of dermal-binding pemphigoid diseases by detecting autoantibodies against laminin β4, type VII collagen and laminin 332. Results showed high sensitivity, with anti-p200 pemphigoid (laminin β4 reactivity) being more frequent than epidermolysis bullosa acquisita, suggesting underdiagnosis in clinical practice. The Biochip mosaic is a valuable tool for the parallel detection of key autoantibodies, potentially enhancing diagnostic accuracy and patient management.
Standardized indirect immunofluorescence-based detection of dermal-binding autoantibodies in pemphigoid diseases: a prospective international multicentre study / Patzelt, S., Engin, R.M., Drenovska, K., Kiehne, C., Probst, C., Komorowski, L., Mindorf, S., Daneshpazhooh, M., Kim, S.-C., Farnetani, F., Vaschieri, C., Rao, R., Marzano, A.V., Dmochowski, M., Patsatsi, A., Murrell, D., Kern, J.S., Karakok Kisla, H., Sprecher, E., De, D., et al.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 194:1(2026), pp. 163-165. [10.1093/bjd/ljaf385]
Standardized indirect immunofluorescence-based detection of dermal-binding autoantibodies in pemphigoid diseases: a prospective international multicentre study
Farnetani F.;Vaschieri C.Membro del Collaboration Group
;Zhu X.;
2026
Abstract
We evaluated a Biochip™-based immunofluorescence assay for improved diagnosis of dermal-binding pemphigoid diseases by detecting autoantibodies against laminin β4, type VII collagen and laminin 332. Results showed high sensitivity, with anti-p200 pemphigoid (laminin β4 reactivity) being more frequent than epidermolysis bullosa acquisita, suggesting underdiagnosis in clinical practice. The Biochip mosaic is a valuable tool for the parallel detection of key autoantibodies, potentially enhancing diagnostic accuracy and patient management.
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