We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PDwildtype) and in 129 samples from PD participants with GBA1 variants (PDGBA1). While Alzheimer profiles increased with age in PDwildtype, it was sparse in PDGBA1. Alpha-Synuclein profiles remained stable with age in both cohorts. In PDwildtype, combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.
Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants / Lerche, S., Wurster, I., Roeben, B., Zimmermann, M., Rossi, M., Mammana, A., Baiardi, S., Hauser, A., Deuschle, C., Schulte, C., Parchi, P., Brockmann, K.. - In: NPJ PARKINSON'S DISEASE. - ISSN 2373-8057. - 11:1(2025), pp. 107-107. [10.1038/s41531-025-00978-1]
Differences in age-related distribution of CSF alpha-synuclein seeding and Alzheimer profiles between PD with and without GBA1 variants
Marcello Rossi;
2025
Abstract
We studied the age- and genetic-related prevalence of CSF alpha-Synuclein seeding and Alzheimer profiles in 188 samples from PD participants without GBA1 variants (PDwildtype) and in 129 samples from PD participants with GBA1 variants (PDGBA1). While Alzheimer profiles increased with age in PDwildtype, it was sparse in PDGBA1. Alpha-Synuclein profiles remained stable with age in both cohorts. In PDwildtype, combined alpha-Synuclein/Alzheimer profiles were associated with earlier onset of cognitive impairment.
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