A recent Danish memory clinic cohort study sheds light on the enigmatic A-T+ biomarker profile - defined by elevated CSF p-tau181 in the absence of amyloid pathology. This commentary explores the clinical and conceptual implications of A-T+, arguing that it reflects a heterogeneous, non-Alzheimer group and highlighting the need to rethink A-T+ within a broader neurobiological framework. A-T+ is not diagnostic noise, but a call to investigate diverse pathways of neurodegeneration beyond amyloid-tau paradigms.
Deciphering the A–T+ enigma: Clinical relevance or diagnostic noise? / Salemme, S.; Chiari, A.; Zamboni, G.; Tondelli, M.. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 107:4(2025), pp. 1404-1405. [10.1177/13872877251366661]
Deciphering the A–T+ enigma: Clinical relevance or diagnostic noise?
Salemme S.
;Zamboni G.;
2025
Abstract
A recent Danish memory clinic cohort study sheds light on the enigmatic A-T+ biomarker profile - defined by elevated CSF p-tau181 in the absence of amyloid pathology. This commentary explores the clinical and conceptual implications of A-T+, arguing that it reflects a heterogeneous, non-Alzheimer group and highlighting the need to rethink A-T+ within a broader neurobiological framework. A-T+ is not diagnostic noise, but a call to investigate diverse pathways of neurodegeneration beyond amyloid-tau paradigms.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
