The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer

Chansky, K.; Detterbeck, F. C.; Nicholson, A. G.; Rusch, V. W.; Vallieres, E.; Groome, P.; Kennedy, C.; Krasnik, M.; Peake, M.; Shemanski, L.; Bolejack, V.; Crowley, J. J.; Asamura, H.; Rami-Porta, R.; Goldstraw, P.; Rami-Porta, R.; Ball, D.; Beer, D. G.; Beyruti, R.; Bolejack, V.; Crowley, J.; Detterbeck, F.; Erich Eberhardt, W. E.; Edwards, J.; Galateau-Salle, F.; Giroux, D.; Gleeson, F.; Groome, P.; Huang, J.; Kennedy, C.; Kim, J.; Kim, Y. T.; Kingsbury, L.; Kondo, H.; Krasnik, M.; Kubota, K.; Lerut, A.; Lyons, G.; Marino, M.; Marom, E. M.; Van Meerbeeck, J.; Mitchell, A.; Nakano, T.; Nicholson, A. G.; Nowak, A.; Peake, M.; Rice, T.; Rosenzweig, K.; Ruffini, E.; Saijo, N.; Van Schil, P.; Sculier, J. -P.; Shemanski, L.; Stratton, K.; Suzuki, K.; Tachimori, Y.; Thomas, C. F.; Travis, W.; Tsao, M. S.; Turrisi, A.; Vansteenkiste, J.; Watanabe, H.; Y. -L., Wu; Baas, P.; Erasmus, J.; Hasegawa, S.; Inai, K.; Kernstine, K.; Kindler, H.; Krug, L.; Nackaerts, K.; Pass, H.; Rice, D.; Falkson, C.; Filosso, P. L.; Giaccone, G.; Kondo, K.; Lucchi, M.; Okumura, M.; Blackstone, E.; Cavaco, F. A.; Barrera, E. A.; Arca, J. A.; Lamelas, I. P.; Obrer, A. A.; Jorge, R. G.; Ball, D.; Bascom, G. K.; Orozco, A. I. B.; Castro, M. A. G.; Blum, M. G.; Chimondeguy, D.; Cvijanovic, V.; Defranchi, S.; De Olaiz Navarro, B.; Campuzano, I. E.; Vidueira, I. M.; Araujo, E. F.; Garcia, F. A.; Fong, K. M.; Corral, G. F.; Gonzalez, S. C.; Gilart, J. F.; Aranguena, L. G.; Barajas, S. G.; Girard, P.; Goksel, T.; Budino, M. T. G.; Casaurran, G. G.; Blanco, J. A. G.; Hernandez, J. H.; Rodriguez, H. H.; Collantes, J. H.; Heras, M. I.; Elena, J. M. I.; Jakobsen, E.; Kostas, S.; Atance, P. L.; Ares, A. N.; Liao, M.; Losanovscky, M.; Lyons, G.; Magaroles, R.; De Esteban Julvez, L.; Gorospe, M. M.; Mccaughan, B.; Kennedy, C.; Iniguez, R. M.; Sorribes, L. M.; Gozalo, S. N.; Alvarez De Arriba, C.; Delgado, M. N.; Alarcon, J. P.; Cuesta, J. C. P.; Park, J. S.; Fernandez, M. J. P.; Rosenberg, M.; Sanchez De Cos Escuin, J.; Vinuesa, A. S.; Mitjans, M. S.; Strand, T. E.; Subotic, D.; Swisher, S.; Terra, R.; Thomas, C.; Tournoy, K.; Velasquez, M.; Yokoi, K.

doi:10.1016/j.jtho.2017.04.011

Introduction Revisions to the TNM stage classifications for lung cancer, informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external validation. The objective was to externally validate the revisions by using the National Cancer Data Base (NCDB) of the American College of Surgeons. Methods Cases presenting from 2000 through 2012 were drawn from the NCDB and reclassified according to the eighth edition stage classification. Clinically and pathologically staged subsets of NSCLC were analyzed separately. The T, N, and overall TNM classifications were evaluated according to clinical, pathologic, and “best” stage (N = 780,294). Multivariate analyses were carried out to adjust for various confounding factors. A combined analysis of the NSCLC cases from both databases was performed to explore differences in overall survival prognosis between the two databases. Results The databases differed in terms of key factors related to data source. Survival was greater in the IASLC database for all stage categories. However, the eighth edition TNM stage classification system demonstrated consistent ability to discriminate TNM categories and stage groups for clinical and pathologic stage. Conclusions The IASLC revisions made for the eighth edition of lung cancer staging are validated by this analysis of the NCDB database by the ordering, statistical differences, and homogeneity within stage groups and by the consistency within analyses of specific cohorts.

The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer / Chansky, K., Detterbeck, F.C., Nicholson, A.G., Rusch, V.W., Vallieres, E., Groome, P., Kennedy, C., Krasnik, M., Peake, M., Shemanski, L., Bolejack, V., Crowley, J.J., Asamura, H., Rami-Porta, R., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D.G., Beyruti, R., Bolejack, V., et al.. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 12:7(2017), pp. 1109-1121. [10.1016/j.jtho.2017.04.011]

The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer

Chansky K.;Detterbeck F. C.;Nicholson A. G.;Rusch V. W.;Vallieres E.;Groome P.;Kennedy C.;Krasnik M.;Peake M.;Shemanski L.;Bolejack V.;Crowley J. J.;Asamura H.;Rami-Porta R.;Goldstraw P.;Rami-Porta R.;Ball D.;Beer D. G.;Beyruti R.;Bolejack V.;Crowley J.;Detterbeck F.;Erich Eberhardt W. E.;Edwards J.;Galateau-Salle F.;Giroux D.;Gleeson F.;Groome P.;Huang J.;Kennedy C.;Kim J.;Kim Y. T.;Kingsbury L.;Kondo H.;Krasnik M.;Kubota K.;Lerut A.;Lyons G.;Marino M.;Marom E. M.;van Meerbeeck J.;Mitchell A.;Nakano T.;Nicholson A. G.;Nowak A.;Peake M.;Rice T.;Rosenzweig K.;Ruffini E.;Saijo N.;Van Schil P.;Sculier J. -P.;Shemanski L.;Stratton K.;Suzuki K.;Tachimori Y.;Thomas C. F.;Travis W.;Tsao M. S.;Turrisi A.;Vansteenkiste J.;Watanabe H.;Wu Y. -L.;Baas P.;Erasmus J.;Hasegawa S.;Inai K.;Kernstine K.;Kindler H.;Krug L.;Nackaerts K.;Pass H.;Rice D.;Falkson C.;Filosso P. L.;Giaccone G.;Kondo K.;Lucchi M.;Okumura M.;Blackstone E.;Cavaco F. A.;Barrera E. A.;Arca J. A.;Lamelas I. P.;Obrer A. A.;Jorge R. G.;Ball D.;Bascom G. K.;Orozco A. I. B.;Castro M. A. G.;Blum M. G.;Chimondeguy D.;Cvijanovic V.;Defranchi S.;de Olaiz Navarro B.;Campuzano I. E.;Vidueira I. M.;Araujo E. F.;Garcia F. A.;Fong K. M.;Corral G. F.;Gonzalez S. C.;Gilart J. F.;Aranguena L. G.;Barajas S. G.;Girard P.;Goksel T.;Budino M. T. G.;Casaurran G. G.;Blanco J. A. G.;Hernandez J. H.;Rodriguez H. H.;Collantes J. H.;Heras M. I.;Elena J. M. I.;Jakobsen E.;Kostas S.;Atance P. L.;Ares A. N.;Liao M.;Losanovscky M.;Lyons G.;Magaroles R.;De Esteban Julvez L.;Gorospe M. M.;McCaughan B.;Kennedy C.;Iniguez R. M.;Sorribes L. M.;Gozalo S. N.;Alvarez de Arriba C.;Delgado M. N.;Alarcon J. P.;Cuesta J. C. P.;Park J. S.;Fernandez M. J. P.;Rosenberg M.;Sanchez de Cos Escuin J.;Vinuesa A. S.;Mitjans M. S.;Strand T. E.;Subotic D.;Swisher S.;Terra R.;Thomas C.;Tournoy K.;Velasquez M.;Yokoi K.

2017

Abstract

Introduction Revisions to the TNM stage classifications for lung cancer, informed by the international database (N = 94,708) of the International Association for the Study of Lung Cancer (IASLC) Staging and Prognostic Factors Committee, need external validation. The objective was to externally validate the revisions by using the National Cancer Data Base (NCDB) of the American College of Surgeons. Methods Cases presenting from 2000 through 2012 were drawn from the NCDB and reclassified according to the eighth edition stage classification. Clinically and pathologically staged subsets of NSCLC were analyzed separately. The T, N, and overall TNM classifications were evaluated according to clinical, pathologic, and “best” stage (N = 780,294). Multivariate analyses were carried out to adjust for various confounding factors. A combined analysis of the NSCLC cases from both databases was performed to explore differences in overall survival prognosis between the two databases. Results The databases differed in terms of key factors related to data source. Survival was greater in the IASLC database for all stage categories. However, the eighth edition TNM stage classification system demonstrated consistent ability to discriminate TNM categories and stage groups for clinical and pathologic stage. Conclusions The IASLC revisions made for the eighth edition of lung cancer staging are validated by this analysis of the NCDB database by the ordering, statistical differences, and homogeneity within stage groups and by the consistency within analyses of specific cohorts.

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	Anno di pubblicazione
	
				2017
			
	Rivista
	
				JOURNAL OF THORACIC ONCOLOGY
			
	N° del Volume
	
				12
			
	Fascicolo
	
				7
			
	Pagina iniziale
	
				1109
			
	Pagina finale
	
				1121
			
	Codice DOI
	
				https://dx.doi.org/10.1016/j.jtho.2017.04.011
			
	Codice Scopus
	
				2-s2.0-85019863693
			
	Codice PubMed
	
				28461257
			
	Citazione
	
				The IASLC Lung Cancer Staging Project: External Validation of the Revision of the TNM Stage Groupings in the Eighth Edition of the TNM Classification of Lung Cancer / Chansky, K., Detterbeck, F.C., Nicholson, A.G., Rusch, V.W., Vallieres, E., Groome, P., Kennedy, C., Krasnik, M., Peake, M., Shemanski, L., Bolejack, V., Crowley, J.J., Asamura, H., Rami-Porta, R., Goldstraw, P., Rami-Porta, R., Ball, D., Beer, D.G., Beyruti, R., Bolejack, V., et al.. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 12:7(2017), pp. 1109-1121. [10.1016/j.jtho.2017.04.011]
			
	Tutti gli autori
	
						Chansky, K.; Detterbeck, F. C.; Nicholson, A. G.; Rusch, V. W.; Vallieres, E.; Groome, P.; Kennedy, C.; Krasnik, M.; Peake, M.; Shemanski, L.; Bolejac...espandi
						
	Tipologia
	
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