Spectral Domain OCT Analysis of Reticular Pseudodrusen Progression

Purpose: To analyze reticular pseudodrusen progression over time using spectral domain OCT (SD-OCT). Methods: SD-OCT scans of consecutive patients with reticular pseudodrusen were analyzed at baseline (first SD-OCT examination) and 24 ± 2 months later using eye-tracking software for repeated OCT examination. Results: At baseline, SD-OCT scans of 48 included eyes showed collections of various sized material above the retinal pigment epithelium. Twenty-four months later, on SD-OCT scans guided on first examination, most of this material either thickened or faded, accompanied by inner segment/outer segment junction disruption and loss. Conclusion: Progression of reticular pseudodrusen is accompanied by photoreceptor disruption and loss.