Enhanced Depth Imaging Optical Coherence Tomography in Type 2 Diabetes

PURPOSE. To investigate the changes in macular choroidal thickness in eyes with various stages of diabetic retinopathy, using enhanced depth imaging optical coherence tomography (EDI OCT). METHODS. Sixty-three consecutive diabetic patients-who presented without diabetic retinopathy (NDR); with diabetic retinopathy (nonproliferative diabetic retinopathy [NPDR]) and no clinically significant macular edema (CSME+); or with NDPR and clinically significant macular edema (CSME+)-underwent EDI OCT. Twenty-one age-and sex-matched healthy subjects (21 eyes) also underwent EDI OCT. RESULTS. A total of 63 eyes of 63 consecutive diabetic patients (26 female [41.2%]; mean age 65 +/- 9 years, range 48-83 years) were included in the analysis. Mean best-corrected visual acuity was 0.13 +/- 0.25 LogMAR (range 0-1). Mean CMT was 272.5 +/- 16.2 mu m in 21 NDR eyes, 294.5 +/- 23.5 mu m in 21 NPDR/CSME- eyes, and 385.6 +/- 75.1 mu m in 21 NPDR/CSME+ eyes. There was no difference in mean subfoveal choroidal thickness among each diabetic group (238.4 +/- 47.9 mu m [NDR], 207.0 +/- 55.9 mu m [NPDR/CSME-], 190.8 +/- 48.4 mu m [NPDR/CSME+]; P = 0.23). The mean subfoveal choroidal thickness was significantly reduced in each diabetic group compared with the control group (309.8 +/- 58.5 mu m, P < 0.001). CONCLUSIONS. In diabetic eyes, there is an overall thinning of the choroid on EDI OCT. A decreased choroidal thickness may lead to tissue hypoxia and consequently increase the level of VEGF, resulting in the breakdown of the blood-retinal barrier and development of macular edema. (Invest Ophthalmol Vis Sci. 2012; 53: 6017-6024) DOI: 10.1167/iovs.12-9692