No More Slice Wars: Towards Harmonized Brain MRI Synthesis for the BraSyn Challenge

The synthesis of missing MRI modalities has emerged as a critical solution to address incomplete multi-parametric imaging in brain tumor diagnosis and treatment planning. While recent advances in generative models, especially GANs and diffusion-based approaches, have demonstrated promising results in cross-modality MRI generation, challenges remain in preserving anatomical fidelity and minimizing synthesis artifacts. In this work, we build upon the Hybrid Fusion GAN (\hfgan) framework, introducing several enhancements aimed at improving synthesis quality and generalization across tumor types. Specifically, we incorporate z-score normalization, optimize network components for faster and more stable training, and extend the pipeline to support multi-view generation across various brain tumor categories, including gliomas, metastases, and meningiomas. Our approach focuses on refining 2D slice-based generation to ensure intra-slice coherence and reduce intensity inconsistencies, ultimately supporting more accurate and robust tumor segmentation in scenarios with missing imaging modalities. Our source code is available at https://github.com/AImageLab-zip/BraSyn25.