Isolated spinal artery aneurysm treatment: a systematic review of the literature and an illustrative case of the neuromonitoring-assisted resection

INTRODUCTION: Isolated spinal artery aneurysms (ISAAs) are rare, often presenting with sub-arachnoid hemorrhage (SAH) and severe neurological deficits. Conclusive evidence about the best management approach is lacking. EVIDENCE ACQUISITION: Following PRISMA guidelines, a systematic review of papers about ISAAs management was conducted from 1966 to 2024, evaluating age, sex, risk factors/comorbidities, aneurysm rupture and location, treatment modalities and clinical outcome. An illustrative case of a 65-year-old woman with a an ISAA of a radiculomedullary artery at T8 level was reported. EVIDENCE SYNTHESIS: Overall, 106 studies obtained from the literature review showed 138 patients received an ISAA diagnosis and were managed with surgery (52.1%), observation (31.1%), or endovascular treatment (11.5%), with clinical improvement in 76.4%, 86%, 81.2% of cases, respectively. The treatment option was not reported in 5.3% of cases. Only two patients presented neurological worsening related to vasospasm, and none had rebleeding after treatment. The mean follow-up was 8.7 months (range 0.03-73 months). In the reported illustrative case, after left T7-T8 laminectomy and dural opening, a little thrombosed aneurysm was found. Under doppler and neurophysiological monitoring, temporary clips were placed on the afferent and efferent vessel and the aneurysm was resected. The patient reported complete and stable regression of symptoms. No complications were detected after 6 months. Imaging showed complete resection of the aneurysm. CONCLUSIONS: Surgical resection under neurophysiological monitoring is an excellent treatment option to both eliminate the risk of rebleeding, while preserving the neurological function. Observation and endovascular treatment may lead to comparable neurological outcomes. Larger multicentric studies with longer follow-up are needed to determine the best management option. (Cite this article as: Serpico F, Meola A, Saturno Spurio F, Iaccarino C, Pavesi G, Tacconi L. Isolated spinal artery aneurysm treatment: a systematic review of the literature and an illustrative case of the neuromonitoring-assisted resection. J Neurosurg Sci 2025 Aug 01. DOI: 10.23736/ S0390-5616.25.06529-4)