In candidates for hepatectomy, different techniques to induce liver hypertrophy and modulate the future liver remnant are available. However, their use in specific clinical scenarios is highly heterogeneous and there is no consensus about minimal safety standards needed to incorporate these strategies into routine clinical practice. The aim of this position paper was to summarize newly available evidence in the field and compare medical practice among different hepatobiliary surgical units to evaluate the transformative potential of liver hypertrophy techniques in surgical oncology. This paper sets the stage for a future structured consensus on the application of liver hypertrophy techniques before hepatectomy.
Liver hypertrophy techniques: a position paper from the Italian Group of Regenerative and Occlusive Worldwide-used techniques of hepatic Hypertrophy (I GROWtoH) / Serenari, Matteo; Ratti, Francesca; Hilal, Mohammed Abu; Ardito, Francesco; Berardi, Giammauro; Boggi, Ugo; Cappelli, Alberta; Cescon, Matteo; Cillo, Umberto; Cucchetti, Alessandro; De Carlis, Luciano; De Cobelli, Francesco; Di Benedetto, Fabrizio; Ercolani, Giorgio; Ettorre, Giuseppe Maria; Fedi, Massimo; Ferrero, Alessandro; Giuliante, Felice; Grazi, Gian Luca; Gringeri, Enrico; Gruttadauria, Salvatore; Izzo, Francesco; Maestri, Marcello; Magistri, Paolo; Massani, Marco; Mazzaferro, Vincenzo; Memeo, Riccardo; Mocchegiani, Federico; Mosconi, Cristina; Patrono, Damiano; Ravaioli, Matteo; Romano, Fabrizio; Rompianesi, Gianluca; Russolillo, Nadia; Ruzzenente, Andrea; Sposito, Carlo; Troisi, Roberto; Vennarecci, Giovanni; Viganò, Luca; Vivarelli, Marco; Zanus, Giacomo; Baptista, Pedro M; Oldhafer, Karl; Schadde, Erik; Aldrighetti, Luca; Jovine, Elio. - In: UPDATES IN SURGERY. - ISSN 2038-3312. - (2025), pp. 1-17. [10.1007/s13304-025-02364-1]
Liver hypertrophy techniques: a position paper from the Italian Group of Regenerative and Occlusive Worldwide-used techniques of hepatic Hypertrophy (I GROWtoH)
Di Benedetto, Fabrizio;Magistri, Paolo;
2025
Abstract
In candidates for hepatectomy, different techniques to induce liver hypertrophy and modulate the future liver remnant are available. However, their use in specific clinical scenarios is highly heterogeneous and there is no consensus about minimal safety standards needed to incorporate these strategies into routine clinical practice. The aim of this position paper was to summarize newly available evidence in the field and compare medical practice among different hepatobiliary surgical units to evaluate the transformative potential of liver hypertrophy techniques in surgical oncology. This paper sets the stage for a future structured consensus on the application of liver hypertrophy techniques before hepatectomy.
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