In December 2022, Gerwin et al published in Nature Medicine that the C-terminal portion of angiopoietin-like 3, called LNA043, has chondroprotective and cartilage-regenerative properties. Molecular data from an experimental medicine phase I study suggested potential efficacy in humans. Here, we respond to and complement a commentary from Vincent and Conaghan and discuss unresolved issues and the potential of this molecule as a disease-modifying osteoarthritis drug.
Towards disease modification in osteoarthritis / Dell'Accio, F.; De Bari, C.. - In: OSTEOARTHRITIS AND CARTILAGE. - ISSN 1063-4584. - 31:9(2023), pp. 1154-1155. [10.1016/j.joca.2023.05.002]
Towards disease modification in osteoarthritis
De Bari C.
2023
Abstract
In December 2022, Gerwin et al published in Nature Medicine that the C-terminal portion of angiopoietin-like 3, called LNA043, has chondroprotective and cartilage-regenerative properties. Molecular data from an experimental medicine phase I study suggested potential efficacy in humans. Here, we respond to and complement a commentary from Vincent and Conaghan and discuss unresolved issues and the potential of this molecule as a disease-modifying osteoarthritis drug.
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