In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed.
Enabling protein-hosted organocatalytic transformations / Nodling, A. R.; Santi, N.; Williams, T. L.; Tsai, Y. -H.; Luk, L. Y. P.. - In: RSC ADVANCES. - ISSN 2046-2069. - 10:27(2020), pp. 16147-16161. [10.1039/d0ra01526a]
Enabling protein-hosted organocatalytic transformations
Santi N.;
2020
Abstract
In this review, the development of organocatalytic artificial enzymes will be discussed. This area of protein engineering research has underlying importance, as it enhances the biocompatibility of organocatalysis for applications in chemical and synthetic biology research whilst expanding the catalytic repertoire of enzymes. The approaches towards the preparation of organocatalytic artificial enzymes, techniques used to improve their performance (selectivity and reactivity) as well as examples of their applications are presented. Challenges and opportunities are also discussed.
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