Immune activation of the monocyte-macrophage population plays a pivotal role in the systemic hyper-inflammatory response, typically observed during severe dysimmune diseases, such as sepsis and COVID-19. In this commentary, we have reviewed the literature data on the novel cytometric marker of monocyte activation, known as MDW (Monocyte Volume Distribution Width), a monocyte dimensional parameter obtainable by blood count examination, which has recently been approved for clinical use as "Early Sepsis Indicator" (ESId), in patients accessing the Emergency Department. In particular, in this Opinion paper, we highlight the main clinical applications and relevant perspectives of this new test: from its use for (early) diagnosis of sepsis, in different hospital settings, to its emerging prognostic role in patients with COVID-19, as a biomarker of disease severity. In view of the reported evidence, we discuss the clinico-pathological notion that, basically, severe COVID-19 can be considered a new form of viral sepsis. Further clinical studies are needed to better understand the pre-analytical and analytical variables of this parameter, correlate MDW dynamics with those of other humoral and cytometric markers, and validate the new diagnostic and prognostic applications of MDW on large multicenter case series.

From sepsis to COVID-19: the emerging role of Monocyte Distribution Width (MDW) / Riva, G.; Nasillo, V.; Luppi, M.; Tagliafico, E.; Trenti, T.. - In: BIOCHIMICA CLINICA. - ISSN 0393-0564. - 46:4(2022), pp. 336-341. [10.19186/BC_2022.060]

From sepsis to COVID-19: the emerging role of Monocyte Distribution Width (MDW)

Luppi M.;Tagliafico E.;
2022

Abstract

Immune activation of the monocyte-macrophage population plays a pivotal role in the systemic hyper-inflammatory response, typically observed during severe dysimmune diseases, such as sepsis and COVID-19. In this commentary, we have reviewed the literature data on the novel cytometric marker of monocyte activation, known as MDW (Monocyte Volume Distribution Width), a monocyte dimensional parameter obtainable by blood count examination, which has recently been approved for clinical use as "Early Sepsis Indicator" (ESId), in patients accessing the Emergency Department. In particular, in this Opinion paper, we highlight the main clinical applications and relevant perspectives of this new test: from its use for (early) diagnosis of sepsis, in different hospital settings, to its emerging prognostic role in patients with COVID-19, as a biomarker of disease severity. In view of the reported evidence, we discuss the clinico-pathological notion that, basically, severe COVID-19 can be considered a new form of viral sepsis. Further clinical studies are needed to better understand the pre-analytical and analytical variables of this parameter, correlate MDW dynamics with those of other humoral and cytometric markers, and validate the new diagnostic and prognostic applications of MDW on large multicenter case series.
2022
46
4
336
341
From sepsis to COVID-19: the emerging role of Monocyte Distribution Width (MDW) / Riva, G.; Nasillo, V.; Luppi, M.; Tagliafico, E.; Trenti, T.. - In: BIOCHIMICA CLINICA. - ISSN 0393-0564. - 46:4(2022), pp. 336-341. [10.19186/BC_2022.060]
Riva, G.; Nasillo, V.; Luppi, M.; Tagliafico, E.; Trenti, T.
File in questo prodotto:
File Dimensione Formato  
Riva et al_Biochimica Clinica_2022.pdf

Accesso riservato

Tipologia: VOR - Versione pubblicata dall'editore
Dimensione 395.79 kB
Formato Adobe PDF
395.79 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1367970
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact