The mechanism whereby mitochondrial DNA (mtDNA) is released into the cytosol and activates the cGAS/STING inflammatory pathway during Bax/Bax-mediated apoptosis is unknown. In this issue, Riley et al (2018) report that widening of Bax and Bak pores on the mitochondrial outer membrane (MOM) during apoptosis allows the extrusion of the mitochondrial inner membrane (MIM) into the cytosol and its permeabilization to release mtDNA independently of caspases. In this scenario, Bax and Bak emerge as key modulators of the apoptotic immunogenic response.
MIM through MOM: The awakening of bax and bak pores / Cosentino, K.; Garcia-Saez, A. J.. - In: EMBO JOURNAL. - ISSN 0261-4189. - 37:17(2018). [10.15252/embj.2018100340]
MIM through MOM: The awakening of bax and bak pores
Cosentino K.;
2018
Abstract
The mechanism whereby mitochondrial DNA (mtDNA) is released into the cytosol and activates the cGAS/STING inflammatory pathway during Bax/Bax-mediated apoptosis is unknown. In this issue, Riley et al (2018) report that widening of Bax and Bak pores on the mitochondrial outer membrane (MOM) during apoptosis allows the extrusion of the mitochondrial inner membrane (MIM) into the cytosol and its permeabilization to release mtDNA independently of caspases. In this scenario, Bax and Bak emerge as key modulators of the apoptotic immunogenic response.
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