In this paper, we consider optimal control problems for a parabolic system modeling a therapy, based on oncolytic viruses, for the glioma brain cancer. Using several techniques typical of functional analysis, we prove the global in time well posedness of the control model, the existence of optimal controls for specific objective functionals, which are natural for cancer therapies, and we derive necessary conditions for optimality.
Optimal control problems for a parabolic system inspired by a cancer therapy / Garavello, Mauro; Rossi, Elena. - In: ZEITSCHRIFT FUR ANALYSIS UND IHRE ANWENDUNGEN. - ISSN 0232-2064. - 44:3/4(2025), pp. 355-388. [10.4171/ZAA/1775]
Optimal control problems for a parabolic system inspired by a cancer therapy
Elena Rossi
2025
Abstract
In this paper, we consider optimal control problems for a parabolic system modeling a therapy, based on oncolytic viruses, for the glioma brain cancer. Using several techniques typical of functional analysis, we prove the global in time well posedness of the control model, the existence of optimal controls for specific objective functionals, which are natural for cancer therapies, and we derive necessary conditions for optimality.
| File | Dimensione | Formato | |
|---|---|---|---|
|
ZAA2025.pdf
Open access
Tipologia:
VOR - Versione pubblicata dall'editore
Licenza:
[IR] creative-commons
Dimensione
381.31 kB
Formato
Adobe PDF
|
381.31 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
