Background: Manganese (Mn) is both an essential and toxic metal, and associations with neurodevelopment depend on exposure timing. Prospective data examining early life Mn with adolescent cognition are sparse. Methods: We enrolled 140 Italian adolescents (10–14 years old) from the Public Health Impact of Metals Exposure study. Mn in deciduous teeth was measured using laser ablation-mass spectrometry to represent prenatal, postnatal and early childhood exposure. The California Verbal Learning Test for Children (CVLT-C) was administered to assess adolescent verbal learning and memory. Multivariable regression models estimated changes in CVLT-C scores and the odds of making an error per doubling in dentine Mn in each exposure period. Multiple informant models tested for differences in associations across exposure periods. Results: A doubling in prenatal dentine Mn levels was associated with lower odds of making an intrusion error (OR = 0.23 [95% CI: 0.09, 0.61]). This beneficial association was not observed in other exposure periods. A doubling in childhood Mn was beneficially associated with short delay free recall: (ß = 0.47 [95% CI: −0.02, 0.97]), which was stronger in males (ß = 0.94 [95% CI: 0.05, 1.82]). Associations were null in the postnatal period. Conclusion: Exposure timing is critical for understanding Mn-associated changes in cognitive function.
Early-life manganese exposure during multiple developmental periods and adolescent verbal learning and memory / Friedman, A.; Schildroth, S.; Bauer, J. A.; Coull, B. A.; Smith, D. R.; Placidi, D.; Cagna, G.; Krengel, M. H.; Tripodis, Y.; White, R. F.; Lucchini, R. G.; Wright, R. O.; Horton, M.; Austin, C.; Arora, M.; Claus Henn, B.. - In: NEUROTOXICOLOGY AND TERATOLOGY. - ISSN 0892-0362. - 100:(2023), pp. 1-14. [10.1016/j.ntt.2023.107307]
Early-life manganese exposure during multiple developmental periods and adolescent verbal learning and memory
Lucchini R. G.;
2023
Abstract
Background: Manganese (Mn) is both an essential and toxic metal, and associations with neurodevelopment depend on exposure timing. Prospective data examining early life Mn with adolescent cognition are sparse. Methods: We enrolled 140 Italian adolescents (10–14 years old) from the Public Health Impact of Metals Exposure study. Mn in deciduous teeth was measured using laser ablation-mass spectrometry to represent prenatal, postnatal and early childhood exposure. The California Verbal Learning Test for Children (CVLT-C) was administered to assess adolescent verbal learning and memory. Multivariable regression models estimated changes in CVLT-C scores and the odds of making an error per doubling in dentine Mn in each exposure period. Multiple informant models tested for differences in associations across exposure periods. Results: A doubling in prenatal dentine Mn levels was associated with lower odds of making an intrusion error (OR = 0.23 [95% CI: 0.09, 0.61]). This beneficial association was not observed in other exposure periods. A doubling in childhood Mn was beneficially associated with short delay free recall: (ß = 0.47 [95% CI: −0.02, 0.97]), which was stronger in males (ß = 0.94 [95% CI: 0.05, 1.82]). Associations were null in the postnatal period. Conclusion: Exposure timing is critical for understanding Mn-associated changes in cognitive function.
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