Objective: The study investigated maternal exposure to heavy metals from industrial sources during pregnancy as potential risk factors for childhood cancer. Methods: Cases ages 0-19 were identified from California Cancer Registry. Controls (20:1 ratio) were randomly selected from California Birth Registry, frequency-matched by birth year (1998-2016). We estimated maternal exposure to lead, nickel, and cobalt in ambient air from the Toxics Release Inventory. We examined "ever/never" and "high/low" exposures categorized by median exposure. Models were adjusted for maternal age, race/ethnicity, method of payment for prenatal care, neighborhood socioeconomic status, and urban/rural residence. Results: Among highly exposed persons, lead was associated with an increased teratoma risk (adjusted odds ratio [aOR]: 1.52; 95% confidence interval [CI]: 0.97, 2.37), whereas nickel was associated with an increased rhabdomyosarcoma risk (aOR: 1.45; 95% CI: 1.03, 2.04). Cobaltwas associated with an increased glioma risk (aOR: 2.25; 95% CI: 1.39, 3.65) among ever-exposed persons. Inverse associations were found between Wilms tumor and nickel among the ever exposed and highly exposed (ever: aOR: 0.75; 95% CI: 0.59, 0.96; high: aOR: 0.64; 95% CI: 0.45, 0.93). Conclusions: Findings suggest that air pollution from heavy metals released by industrial sources may elevate childhood cancer risk.

Maternal Exposure to Heavy Metals from Industrial Sources during Pregnancy and Childhood Cancer Risk in California / Chen, Y.; Van Deventer, D.; Nianogo, R.; Vinceti, M.; Kang, W.; Cockburn, M.; Federman, N.; Heck, J. E.. - In: JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. - ISSN 1076-2752. - 66:9(2024), pp. 714-721. [10.1097/JOM.0000000000003160]

Maternal Exposure to Heavy Metals from Industrial Sources during Pregnancy and Childhood Cancer Risk in California

Vinceti M.;
2024

Abstract

Objective: The study investigated maternal exposure to heavy metals from industrial sources during pregnancy as potential risk factors for childhood cancer. Methods: Cases ages 0-19 were identified from California Cancer Registry. Controls (20:1 ratio) were randomly selected from California Birth Registry, frequency-matched by birth year (1998-2016). We estimated maternal exposure to lead, nickel, and cobalt in ambient air from the Toxics Release Inventory. We examined "ever/never" and "high/low" exposures categorized by median exposure. Models were adjusted for maternal age, race/ethnicity, method of payment for prenatal care, neighborhood socioeconomic status, and urban/rural residence. Results: Among highly exposed persons, lead was associated with an increased teratoma risk (adjusted odds ratio [aOR]: 1.52; 95% confidence interval [CI]: 0.97, 2.37), whereas nickel was associated with an increased rhabdomyosarcoma risk (aOR: 1.45; 95% CI: 1.03, 2.04). Cobaltwas associated with an increased glioma risk (aOR: 2.25; 95% CI: 1.39, 3.65) among ever-exposed persons. Inverse associations were found between Wilms tumor and nickel among the ever exposed and highly exposed (ever: aOR: 0.75; 95% CI: 0.59, 0.96; high: aOR: 0.64; 95% CI: 0.45, 0.93). Conclusions: Findings suggest that air pollution from heavy metals released by industrial sources may elevate childhood cancer risk.
2024
66
9
714
721
Maternal Exposure to Heavy Metals from Industrial Sources during Pregnancy and Childhood Cancer Risk in California / Chen, Y.; Van Deventer, D.; Nianogo, R.; Vinceti, M.; Kang, W.; Cockburn, M.; Federman, N.; Heck, J. E.. - In: JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. - ISSN 1076-2752. - 66:9(2024), pp. 714-721. [10.1097/JOM.0000000000003160]
Chen, Y.; Van Deventer, D.; Nianogo, R.; Vinceti, M.; Kang, W.; Cockburn, M.; Federman, N.; Heck, J. E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1357966
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