Tris-(2-pyridylmethyl)amines (TPA or TPMA) are polipyrydine-based ligands extensively used in catalysis and supramolecular chemistry due their capability to form stable tetradentate complexes with a large variety of metals. The unsubstituted ligand, which is also commercially available, can be synthesised by consecutive alkylation of a picoline or by reductive amination of a pyridine aldehyde. In this article, we report a novel synthetic method which opens to the post-functionalisation of these ligands in the benzylic position. This novel derivatization strategy, beside providing synthetic access to novel structures and functions, has been used to prepare a series of metal complexes which have been tested in photochemical hydrogen evolution.A novel synthetic protocol allows the direct functionalisation of tris-(2-pyridylmethyl)amines (TPA or TPMA) in the benzylic position.
Novel ligands from direct benzylic functionalisation of tris(2-pyridylmethyl)amine / Zardi, Paolo; Piękoś, Justyna; Bravin, Carlo; Wurst, Klaus; Droghetti, Federico; Natali, Mirco; Licini, Giulia; Zambon, Alfonso; Zonta, Cristiano. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 53:33(2024), pp. 13831-13836. [10.1039/d4dt02022g]
Novel ligands from direct benzylic functionalisation of tris(2-pyridylmethyl)amine
Zardi, Paolo;Zambon, Alfonso;
2024
Abstract
Tris-(2-pyridylmethyl)amines (TPA or TPMA) are polipyrydine-based ligands extensively used in catalysis and supramolecular chemistry due their capability to form stable tetradentate complexes with a large variety of metals. The unsubstituted ligand, which is also commercially available, can be synthesised by consecutive alkylation of a picoline or by reductive amination of a pyridine aldehyde. In this article, we report a novel synthetic method which opens to the post-functionalisation of these ligands in the benzylic position. This novel derivatization strategy, beside providing synthetic access to novel structures and functions, has been used to prepare a series of metal complexes which have been tested in photochemical hydrogen evolution.A novel synthetic protocol allows the direct functionalisation of tris-(2-pyridylmethyl)amines (TPA or TPMA) in the benzylic position.File | Dimensione | Formato | |
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