A 9-Tetrahydrocannabinol ( A 9-THC) is known to be the component of the cannabis plant responsible for the psychoactive effects generated by the activation of the endocannabinoid receptor 1 (CBR1). Following extensive structure-activity relationship (SAR) studies on A 9-THC, new molecules with increased CBR1 affinity were designed and synthesized over the last decades. The knowledge arising from the pharmacological and synthetic investigations has been extensively used in the recent past by the industry of substances for recreational use also thanks to the 2018 Farm Bill Act in the USA and the incentive for low-THC cannabis (hemp) cultivation in Europe, which have boosted the availability of hemp derived precursors. As a result, new semi-synthetic natural and pseudo natural cannabinoids related to the most famous A 9-THC and often not subjected to legal restrictions are now available in the online market in a broad array of retail products with no preventive study on their pharmacodynamics and pharmacokinetics. Some of these products (gummies, cannabis flower and a vape cartridge), all declared to contain the most potent among all the known cannabinoids, A 9-Tetrahydrocannabiphorol ( A 9-THCP), were bought from an online shop and tested through LC-HRMS to determine the effective amount of A 9-THCP and of other cannabinoids. All the three samples were found to contain A 9-THCP in amounts significantly different from those declared by the producer. Moreover, the application of an untargeted metabolomics approach (cannabinomics) enabled the identification of other cannabinoids including the emerging semi-synthetic hexahydrocannabinol (HHC) and tetrahydrocannabidiol (H4-CBD) together with byproducts of synthetic origin.
Δ9-Tetrahydrocannabiphorol: Identification and quantification in recreational products / Caprari, Cristian; Ferri, Elena; Schmid, Martin G.; Del Mercato, Loretta L.; Citti, Cinzia; Cannazza, Giuseppe. - 40:(2024), pp. 1-10. [10.1016/j.forc.2024.100595]
Δ9-Tetrahydrocannabiphorol: Identification and quantification in recreational products
Ferri, Elena;Citti, Cinzia;Cannazza, Giuseppe
2024
Abstract
A 9-Tetrahydrocannabinol ( A 9-THC) is known to be the component of the cannabis plant responsible for the psychoactive effects generated by the activation of the endocannabinoid receptor 1 (CBR1). Following extensive structure-activity relationship (SAR) studies on A 9-THC, new molecules with increased CBR1 affinity were designed and synthesized over the last decades. The knowledge arising from the pharmacological and synthetic investigations has been extensively used in the recent past by the industry of substances for recreational use also thanks to the 2018 Farm Bill Act in the USA and the incentive for low-THC cannabis (hemp) cultivation in Europe, which have boosted the availability of hemp derived precursors. As a result, new semi-synthetic natural and pseudo natural cannabinoids related to the most famous A 9-THC and often not subjected to legal restrictions are now available in the online market in a broad array of retail products with no preventive study on their pharmacodynamics and pharmacokinetics. Some of these products (gummies, cannabis flower and a vape cartridge), all declared to contain the most potent among all the known cannabinoids, A 9-Tetrahydrocannabiphorol ( A 9-THCP), were bought from an online shop and tested through LC-HRMS to determine the effective amount of A 9-THCP and of other cannabinoids. All the three samples were found to contain A 9-THCP in amounts significantly different from those declared by the producer. Moreover, the application of an untargeted metabolomics approach (cannabinomics) enabled the identification of other cannabinoids including the emerging semi-synthetic hexahydrocannabinol (HHC) and tetrahydrocannabidiol (H4-CBD) together with byproducts of synthetic origin.File | Dimensione | Formato | |
---|---|---|---|
Caprari et al. - 2024 - Δ9-Tetrahydrocannabiphorol Identification and qua.pdf
Open access
Tipologia:
Versione pubblicata dall'editore
Dimensione
2.2 MB
Formato
Adobe PDF
|
2.2 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris