Introduction/objective: Multiple sclerosis (MS), is characterized by autoimmune-driven neuroinflammation, axonal degeneration, and demyelination. This study aimed to explore the therapeutic potential of targeting Notch signaling within the central nervous system (CNS) in the context of MS. Understanding the intricate roles of Notch signaling could pave the way for targeted interventions to mitigate MS progression. Methods: A comprehensive literature review was conducted using databases such as PubMed, Web of Science, and Scopus. Keywords such as "Notch signaling," "neuroglial interactions," and "MS" were used. The selection criteria included relevance to neuroglial interactions, peer-reviewed publications, and studies involving animal models of MS. Results: This review highlights the diverse functions of Notch signaling in CNS development, including its regulation of neural stem cell differentiation into neurons, astrocytes, and oligodendrocytes. In the context of MS, Notch signaling has emerged as a promising therapeutic target, exhibiting positive impacts on neuroprotection and remyelination. However, its intricate nature within the CNS necessitates precise modulation for therapeutic efficacy. Conclusion: This study provides a comprehensive overview of the potential therapeutic role of Notch signaling in MS. The findings underscore the significance of Notch modulation for neuroprotection and remyelination, emphasizing the need for precision in therapeutic interventions. Further research is imperative to elucidate the specific underlying mechanisms involved, which will provide a foundation for targeted therapeutic strategies for the management of MS and related neurodegenerative disorders.

Notch Signaling in Central Nervous System: From Cellular Development to Multiple Sclerosis Disease / Askari, Hamid; Rabiei, Fatemeh; Biagini, Giuseppe; Yahyazadeh, Masoomeh; Ghasemi-Kasman, Maryam. - In: CURRENT NEUROPHARMACOLOGY. - ISSN 1875-6190. - 23:(2025), pp. 3-19. [10.2174/1570159X22666240731114906]

Notch Signaling in Central Nervous System: From Cellular Development to Multiple Sclerosis Disease

Biagini, Giuseppe
;
2025

Abstract

Introduction/objective: Multiple sclerosis (MS), is characterized by autoimmune-driven neuroinflammation, axonal degeneration, and demyelination. This study aimed to explore the therapeutic potential of targeting Notch signaling within the central nervous system (CNS) in the context of MS. Understanding the intricate roles of Notch signaling could pave the way for targeted interventions to mitigate MS progression. Methods: A comprehensive literature review was conducted using databases such as PubMed, Web of Science, and Scopus. Keywords such as "Notch signaling," "neuroglial interactions," and "MS" were used. The selection criteria included relevance to neuroglial interactions, peer-reviewed publications, and studies involving animal models of MS. Results: This review highlights the diverse functions of Notch signaling in CNS development, including its regulation of neural stem cell differentiation into neurons, astrocytes, and oligodendrocytes. In the context of MS, Notch signaling has emerged as a promising therapeutic target, exhibiting positive impacts on neuroprotection and remyelination. However, its intricate nature within the CNS necessitates precise modulation for therapeutic efficacy. Conclusion: This study provides a comprehensive overview of the potential therapeutic role of Notch signaling in MS. The findings underscore the significance of Notch modulation for neuroprotection and remyelination, emphasizing the need for precision in therapeutic interventions. Further research is imperative to elucidate the specific underlying mechanisms involved, which will provide a foundation for targeted therapeutic strategies for the management of MS and related neurodegenerative disorders.
2025
31-lug-2024
23
3
19
Notch Signaling in Central Nervous System: From Cellular Development to Multiple Sclerosis Disease / Askari, Hamid; Rabiei, Fatemeh; Biagini, Giuseppe; Yahyazadeh, Masoomeh; Ghasemi-Kasman, Maryam. - In: CURRENT NEUROPHARMACOLOGY. - ISSN 1875-6190. - 23:(2025), pp. 3-19. [10.2174/1570159X22666240731114906]
Askari, Hamid; Rabiei, Fatemeh; Biagini, Giuseppe; Yahyazadeh, Masoomeh; Ghasemi-Kasman, Maryam
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1352406
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