The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties encountered in their stabilization. Nanoparticles offer an alternative to improve the physicochemical stability of such biomacromolecules, while increasing their bioavailability by overcoming biological absorption barriers. With this review, we aim to discuss the stability problems of proteins and peptides that have driven the scientific community to find in nanotechnology a valid alternative for oral administration of biomolecules. In addition, we describe the most commonly used nanoparticles for this purpose (e.g., polymers such as polylactic acid, poly(lactic-co-glycolic acid), polycaprolactone, modified chitosan, and lipids such as oil-in-water nanoemulsions, self-emulsified drug delivery systems, solid lipid nanoparticles, nanostructured lipid carriers, liposomes, as well as hybrid systems like micelles), and we show some of the most important recent applications of these nanoparticles for the delivery of proteins and peptides, including for the treatment of diabetes, viruses (such as HIV), cancer, as well as in the development of vaccines.
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems / Berselli, E.; Coccolini, C.; Tosi, G.; Gokce, E. H.; Oliveira, M. B. P. P.; Fathi, F.; Krambeck, K.; Souto, E. B.. - In: INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. - ISSN 1573-3149. - 30:2(2024), pp. 1-15. [10.1007/s10989-024-10592-z]
Therapeutic Peptides and Proteins: Stabilization Challenges and Biomedical Applications by Means of Nanodelivery Systems
Berselli E.;Coccolini C.;Tosi G.;
2024
Abstract
The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties encountered in their stabilization. Nanoparticles offer an alternative to improve the physicochemical stability of such biomacromolecules, while increasing their bioavailability by overcoming biological absorption barriers. With this review, we aim to discuss the stability problems of proteins and peptides that have driven the scientific community to find in nanotechnology a valid alternative for oral administration of biomolecules. In addition, we describe the most commonly used nanoparticles for this purpose (e.g., polymers such as polylactic acid, poly(lactic-co-glycolic acid), polycaprolactone, modified chitosan, and lipids such as oil-in-water nanoemulsions, self-emulsified drug delivery systems, solid lipid nanoparticles, nanostructured lipid carriers, liposomes, as well as hybrid systems like micelles), and we show some of the most important recent applications of these nanoparticles for the delivery of proteins and peptides, including for the treatment of diabetes, viruses (such as HIV), cancer, as well as in the development of vaccines.File | Dimensione | Formato | |
---|---|---|---|
s10989-024-10592-z.pdf
Open access
Tipologia:
Versione pubblicata dall'editore
Dimensione
914.48 kB
Formato
Adobe PDF
|
914.48 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris