Mitragyna speciosa or kratom is emerging worldwide as a “legal” herbal drug of abuse. An increasing number of papers is appearing in the scientific literature regarding its pharmacological profile and the analysis of its chemical constituents, mainly represented by alkaloids. However, its detection and identification are not straightforward as the plant material is not particularly distinctive. Hyphenated techniques are generally preferred for the identification and quantification of these compounds, especially the main purported psychoactive substances, mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG), in raw and commercial products. Considering the vast popularity of this recreational drug and the growing concern about its safety, the analysis of alkaloids in biological specimens is also of great importance for forensic and toxicological laboratories. The review addresses the analytical aspects of kratom spanning the extraction techniques used to isolate the alkaloids, the qualitative and quantitative analytical methods and the strategies for the distinction of the naturally occurring isomers.

Kratom: The analytical challenge of an emerging herbal drug / Citti, C.; Lagana, A.; Capriotti, A. L.; Montone, C. M.; Cannazza, G.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 1703:(2023), pp. 1-1. [10.1016/j.chroma.2023.464094]

Kratom: The analytical challenge of an emerging herbal drug

Citti C.;Cannazza G.
2023

Abstract

Mitragyna speciosa or kratom is emerging worldwide as a “legal” herbal drug of abuse. An increasing number of papers is appearing in the scientific literature regarding its pharmacological profile and the analysis of its chemical constituents, mainly represented by alkaloids. However, its detection and identification are not straightforward as the plant material is not particularly distinctive. Hyphenated techniques are generally preferred for the identification and quantification of these compounds, especially the main purported psychoactive substances, mitragynine (MG) and 7-hydroxymitragynine (7-OH-MG), in raw and commercial products. Considering the vast popularity of this recreational drug and the growing concern about its safety, the analysis of alkaloids in biological specimens is also of great importance for forensic and toxicological laboratories. The review addresses the analytical aspects of kratom spanning the extraction techniques used to isolate the alkaloids, the qualitative and quantitative analytical methods and the strategies for the distinction of the naturally occurring isomers.
2023
1703
1
1
Kratom: The analytical challenge of an emerging herbal drug / Citti, C.; Lagana, A.; Capriotti, A. L.; Montone, C. M.; Cannazza, G.. - In: JOURNAL OF CHROMATOGRAPHY A. - ISSN 0021-9673. - 1703:(2023), pp. 1-1. [10.1016/j.chroma.2023.464094]
Citti, C.; Lagana, A.; Capriotti, A. L.; Montone, C. M.; Cannazza, G.
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