Cortical neurons are often classified by current-frequency relationship. Such a static description is inadequate to interpret neuronal responses to time-varying stimuli. Theoretical studies suggested that single-cell dynamical response properties are necessary to interpret ensemble responses to fast input transients. Further, it was shown that input-noise linearizes and boosts the response bandwidth, and that the interplay between the barrage of noisy synaptic currents and the spike-initiation mechanisms determine the dynamical properties of the firing rate. To test these model predictions, we estimated the linear response properties of layer 5 pyramidal cells by injecting a superposition of a small-amplitude sinusoidal wave and a background noise. We characterized the evoked firing probability across many stimulation trials and a range of oscillation frequencies (1-1000 Hz), quantifying response amplitude and phase-shift while changing noise statistics. We found that neurons track unexpectedly fast transients, as their response amplitude has no attenuation up to 200 Hz. This cut-off frequency is higher than the limits set by passive membrane properties (∼50 Hz) and average firing rate (∼20 Hz) and is not affected by the rate of change of the input. Finally, above 200 Hz, the response amplitude decays as a power-law with an exponent that is independent of voltage fluctuations induced by the background noise. © The Author 2008. Published by Oxford University Press. All rights reserved.

The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro / Koendgen, H; Geisler, C; Fusi, S; Wang, Xj; Luescher, Hr; Giugliano, M. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - 18:9(2008), pp. 2086-2097. [10.1093/cercor/bhm235]

The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro

Giugliano M
2008

Abstract

Cortical neurons are often classified by current-frequency relationship. Such a static description is inadequate to interpret neuronal responses to time-varying stimuli. Theoretical studies suggested that single-cell dynamical response properties are necessary to interpret ensemble responses to fast input transients. Further, it was shown that input-noise linearizes and boosts the response bandwidth, and that the interplay between the barrage of noisy synaptic currents and the spike-initiation mechanisms determine the dynamical properties of the firing rate. To test these model predictions, we estimated the linear response properties of layer 5 pyramidal cells by injecting a superposition of a small-amplitude sinusoidal wave and a background noise. We characterized the evoked firing probability across many stimulation trials and a range of oscillation frequencies (1-1000 Hz), quantifying response amplitude and phase-shift while changing noise statistics. We found that neurons track unexpectedly fast transients, as their response amplitude has no attenuation up to 200 Hz. This cut-off frequency is higher than the limits set by passive membrane properties (∼50 Hz) and average firing rate (∼20 Hz) and is not affected by the rate of change of the input. Finally, above 200 Hz, the response amplitude decays as a power-law with an exponent that is independent of voltage fluctuations induced by the background noise. © The Author 2008. Published by Oxford University Press. All rights reserved.
2008
18
9
2086
2097
The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro / Koendgen, H; Geisler, C; Fusi, S; Wang, Xj; Luescher, Hr; Giugliano, M. - In: CEREBRAL CORTEX. - ISSN 1047-3211. - 18:9(2008), pp. 2086-2097. [10.1093/cercor/bhm235]
Koendgen, H; Geisler, C; Fusi, S; Wang, Xj; Luescher, Hr; Giugliano, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1333727
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