PURPOSE: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens. METHODS: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters. RESULTS: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis. CONCLUSIONS: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk
VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort / Lastraioli, E., Boni, L., Romoli, M.r., Crescioli, S., Taddei, A., Beghelli, S., Tomezzoli, A., Vindigni, C., Saragoni, L., Messerini, L., Bernini, M., Bencini, L., Giommoni, E., Freschi, G., Di Costanzo, F., Scarpa, A., Morgagni, P., Farsi, M., Roviello, F., De Manzoni, G., et al.. - In: EUROPEAN JOURNAL OF SURGICAL ONCOLOGY. - ISSN 0748-7983. - 40:10(2014), pp. 1291-1298. [10.1016/j.ejso.2014.03.028]
VEGF-A clinical significance in gastric cancers: immunohistochemical analysis of a wide Italian cohort
Bernini M;
2014
Abstract
PURPOSE: The clinical significance of VEGF-A expression in gastric cancer (GC) has been reported with contradicting results. We analyzed the expression and clinical significance of VEGF-A in a wide Italian cohort of GC specimens. METHODS: VEGF-A expression was tested by immunohistochemistry in 507 patients with GC of all clinical stages. The impact of VEGF-A on overall survival (OS) was evaluated in conjunction with clinical and pathological parameters. RESULTS: In the Italian cohort we studied VEGF-A was not an independent prognostic factor neither at the univariate nor at multivariate analysis. CONCLUSIONS: Although frequently expressed, in our study VEGF-A was not able to discriminate between groups of patients with different risk
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