We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibrosis. Presenting clinical and laboratory characteristics, including JAK2V617F allele burden, between patients with and without fibrosis were similar for the most part, with the exception of a higher prevalence of palpable splenomegaly in patients with fibrosis (P < .01). Patients with fibrosis were less prone to experience thrombosis during their clinical course (1.1 vs 2.7 per 100 patient-years; P = .03) and more prone to develop post-polycythemia vera myelofibrosis (2.2 vs 0.8 per 100 patient-years; P = .01). There was no significant difference between the 2 groups in terms of overall or leukemia-free survival. The present study clarifies the incidence, degree, and prognostic relevance of bone marrow fibrosis obtained at time of initial diagnosis of polycythemia vera.

Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome / Barbui, T; Thiele, J; Passamonti, F; Rumi, E; Boveri, E; Randi, Ml; Bertozzi, I; Marino, F; Vannucchi, Am; Pieri, L; Rotunno, G; Gisslinger, H; Gisslinger, B; Mullauer, L; Finazzi, G; Carobbio, A; Gianatti, A; Ruggeri, M; Nichele, I; D'Amore, E; Rambaldi, A; Tefferi, A. - In: BLOOD. - ISSN 1528-0020. - 119:10(2012), pp. 2239-2241. [10.1182/blood-2011-11-393819]

Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome

Carobbio A;
2012

Abstract

We examined the prevalence and prognostic relevance of bone marrow reticulin fibrosis in 526 patients with World Health Organization-defined polycythemia vera evaluated at the time of initial diagnosis. Seventy-four patients (14%) displayed mostly grade 1 reticulin fibrosis, with only 2 cases showing higher-grade fibrosis. Presenting clinical and laboratory characteristics, including JAK2V617F allele burden, between patients with and without fibrosis were similar for the most part, with the exception of a higher prevalence of palpable splenomegaly in patients with fibrosis (P < .01). Patients with fibrosis were less prone to experience thrombosis during their clinical course (1.1 vs 2.7 per 100 patient-years; P = .03) and more prone to develop post-polycythemia vera myelofibrosis (2.2 vs 0.8 per 100 patient-years; P = .01). There was no significant difference between the 2 groups in terms of overall or leukemia-free survival. The present study clarifies the incidence, degree, and prognostic relevance of bone marrow fibrosis obtained at time of initial diagnosis of polycythemia vera.
2012
119
10
2239
2241
Initial bone marrow reticulin fibrosis in polycythemia vera exerts an impact on clinical outcome / Barbui, T; Thiele, J; Passamonti, F; Rumi, E; Boveri, E; Randi, Ml; Bertozzi, I; Marino, F; Vannucchi, Am; Pieri, L; Rotunno, G; Gisslinger, H; Gisslinger, B; Mullauer, L; Finazzi, G; Carobbio, A; Gianatti, A; Ruggeri, M; Nichele, I; D'Amore, E; Rambaldi, A; Tefferi, A. - In: BLOOD. - ISSN 1528-0020. - 119:10(2012), pp. 2239-2241. [10.1182/blood-2011-11-393819]
Barbui, T; Thiele, J; Passamonti, F; Rumi, E; Boveri, E; Randi, Ml; Bertozzi, I; Marino, F; Vannucchi, Am; Pieri, L; Rotunno, G; Gisslinger, H; Gisslinger, B; Mullauer, L; Finazzi, G; Carobbio, A; Gianatti, A; Ruggeri, M; Nichele, I; D'Amore, E; Rambaldi, A; Tefferi, A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1331630
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