Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes.

Scaffold and scaffold-free self-assembled systems in regenerative medicine / Thomas, D.; Gaspar, D.; Sorushanova, A.; Milcovich, G.; Spanoudes, K.; Mullen, A. M.; O'Brien, T.; Pandit, A.; Zeugolis, D. I.. - In: BIOTECHNOLOGY AND BIOENGINEERING. - ISSN 0006-3592. - 113:6(2016), pp. 1155-1163. [10.1002/bit.25869]

Scaffold and scaffold-free self-assembled systems in regenerative medicine

Milcovich G.;
2016

Abstract

Self-assembly in tissue engineering refers to the spontaneous chemical or biological association of components to form a distinct functional construct, reminiscent of native tissue. Such self-assembled systems have been widely used to develop platforms for the delivery of therapeutic and/or bioactive molecules and various cell populations. Tissue morphology and functional characteristics have been recapitulated in several self-assembled constructs, designed to incorporate stimuli responsiveness and controlled architecture through spatial confinement or field manipulation. In parallel, owing to substantial functional properties, scaffold-free cell-assembled devices have aided in the development of functional neotissues for various clinical targets. Herein, we discuss recent advancements and future aspirations in scaffold and scaffold-free self-assembled devices for regenerative medicine purposes.
2016
113
6
1155
1163
Scaffold and scaffold-free self-assembled systems in regenerative medicine / Thomas, D.; Gaspar, D.; Sorushanova, A.; Milcovich, G.; Spanoudes, K.; Mullen, A. M.; O'Brien, T.; Pandit, A.; Zeugolis, D. I.. - In: BIOTECHNOLOGY AND BIOENGINEERING. - ISSN 0006-3592. - 113:6(2016), pp. 1155-1163. [10.1002/bit.25869]
Thomas, D.; Gaspar, D.; Sorushanova, A.; Milcovich, G.; Spanoudes, K.; Mullen, A. M.; O'Brien, T.; Pandit, A.; Zeugolis, D. I.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1331477
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