Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid,the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties compa-rable or better than the starting material. This study presents the development of an innovative platformfor viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aimingto reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution withalternative biomaterials. Catanionic vesicles are proposed as physical crosslinker that can guarantee theformation of a ‘soft’, tunable network, offering a dual-therapeutic approach: on the mechanical reliefperspective, as well as on the drug/gene delivery strategy. This research focuses on the fabrication andoptimization of colloidal networks, driven by the synergistic interaction among catanionic vesicles andcationic modified cellulose polymers. This study tests the hypothesis that cellulose-like polymers can bearranged into functional matrix, mimicking the mechanical properties of healthy synovial fluids.

Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid, the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties comparable or better than the starting material. This study presents the development of an innovative platform for viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aiming to reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution with alternative biomaterials. Catanionic vesicles are proposed as physical crosslinker that can guarantee the formation of a ‘soft’, tunable network, offering a dual-therapeutic approach: on the mechanical relief perspective, as well as on the drug/gene delivery strategy. This research focuses on the fabrication and optimization of colloidal networks, driven by the synergistic interaction among catanionic vesicles and cationic modified cellulose polymers. This study tests the hypothesis that cellulose-like polymers can be arranged into functional matrix, mimicking the mechanical properties of healthy synovial fluids.

Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages / Milcovich, Gesmi; Antunes, Filipe E.; Farra, Rossella; Grassi, Gabriele; Grassi, Mario; Asaro, Fioretta. - In: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. - ISSN 0141-8130. - 102:(2017), pp. 796-804. [10.1016/j.ijbiomac.2017.04.079]

Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages

Milcovich, Gesmi;GRASSI, GABRIELE;
2017

Abstract

Viscosupplementation is a therapeutic approach for osteoarthritis treatment, where the synovial fluid, the natural lubricant of the joints, is replaced by viscoelastic solutions with rheological properties comparable or better than the starting material. This study presents the development of an innovative platform for viscosupplementation, based on the optimization of polysaccharide-based colloidal hydrogel, aiming to reduce on-site enzyme degradation and enhance the possibility of hyaluronic acid substitution with alternative biomaterials. Catanionic vesicles are proposed as physical crosslinker that can guarantee the formation of a ‘soft’, tunable network, offering a dual-therapeutic approach: on the mechanical relief perspective, as well as on the drug/gene delivery strategy. This research focuses on the fabrication and optimization of colloidal networks, driven by the synergistic interaction among catanionic vesicles and cationic modified cellulose polymers. This study tests the hypothesis that cellulose-like polymers can be arranged into functional matrix, mimicking the mechanical properties of healthy synovial fluids.
2017
102
796
804
Modulating carbohydrate-based hydrogels as viscoelastic lubricant substitute for articular cartilages / Milcovich, Gesmi; Antunes, Filipe E.; Farra, Rossella; Grassi, Gabriele; Grassi, Mario; Asaro, Fioretta. - In: INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. - ISSN 0141-8130. - 102:(2017), pp. 796-804. [10.1016/j.ijbiomac.2017.04.079]
Milcovich, Gesmi; Antunes, Filipe E.; Farra, Rossella; Grassi, Gabriele; Grassi, Mario; Asaro, Fioretta
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0141813017300843-main.pdf

Accesso riservato

Dimensione 2.68 MB
Formato Adobe PDF
2.68 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1331448
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
social impact