: Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for the development of new effective therapeutics to treat them. Stilbenes, with resveratrol attracting the most attention, are an example of multi-target compounds with promising therapeutic potential for a broad array of neuropsychiatric and neurological conditions. This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disorders. We describe and discuss the results of both in vitro and in vivo studies. The majority of studies concentrate on resveratrol, with limited findings exploring other stilbenes such as pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic resveratrol derivatives. Overall, although extensive preclinical studies show the potential benefits of stilbenes in various central nervous system disorders, clinical evidence on their therapeutic efficacy is largely missing.

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence / Socała, Katarzyna; Żmudzka, Elżbieta; Lustyk, Klaudia; Zagaja, Mirosław; Brighenti, Virginia; Costa, Anna Maria; Andres-Mach, Marta; Pytka, Karolina; Martinelli, Ilaria; Mandrioli, Jessica; Pellati, Federica; Biagini, Giuseppe; Wlaź, Piotr. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - (2024), pp. 1-62. [10.1002/ptr.8101]

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

Brighenti, Virginia;Costa, Anna Maria;Mandrioli, Jessica;Pellati, Federica;Biagini, Giuseppe;
2024

Abstract

: Neuropsychiatric disorders are anticipated to be a leading health concern in the near future, emphasizing an outstanding need for the development of new effective therapeutics to treat them. Stilbenes, with resveratrol attracting the most attention, are an example of multi-target compounds with promising therapeutic potential for a broad array of neuropsychiatric and neurological conditions. This review is a comprehensive summary of the current state of research on stilbenes in several neuropsychiatric and neurological disorders such as depression, anxiety, schizophrenia, autism spectrum disorders, epilepsy, traumatic brain injury, and neurodegenerative disorders. We describe and discuss the results of both in vitro and in vivo studies. The majority of studies concentrate on resveratrol, with limited findings exploring other stilbenes such as pterostilbene, piceatannol, polydatin, tetrahydroxystilbene glucoside, or synthetic resveratrol derivatives. Overall, although extensive preclinical studies show the potential benefits of stilbenes in various central nervous system disorders, clinical evidence on their therapeutic efficacy is largely missing.
2024
18-gen-2024
1
62
Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence / Socała, Katarzyna; Żmudzka, Elżbieta; Lustyk, Klaudia; Zagaja, Mirosław; Brighenti, Virginia; Costa, Anna Maria; Andres-Mach, Marta; Pytka, Karolina; Martinelli, Ilaria; Mandrioli, Jessica; Pellati, Federica; Biagini, Giuseppe; Wlaź, Piotr. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - (2024), pp. 1-62. [10.1002/ptr.8101]
Socała, Katarzyna; Żmudzka, Elżbieta; Lustyk, Klaudia; Zagaja, Mirosław; Brighenti, Virginia; Costa, Anna Maria; Andres-Mach, Marta; Pytka, Karolina; Martinelli, Ilaria; Mandrioli, Jessica; Pellati, Federica; Biagini, Giuseppe; Wlaź, Piotr
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1329886
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