Background The European AIDS Clinical Society (EACS) guidelines were revised in 2023 for the 19th time, and all aspects of HIV care were updated.Key Points of the Guidelines Update Version 12.0 of the guidelines recommend the same six first-line treatment options for antiretroviral treatment (ART)-naive adults as versions 11.0 and 11.1: tenofovir-based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. The long-acting section has been expanded in the ART and drug-drug interaction (DDI) panels. Tables for preferred and alternative ART in children and adolescents have been updated, as has the section on prevention of vertical transmission, particularly with new guidance for breastfeeding. A new DDI table has been included for the ART and anti-infective drugs used for opportunistic infections, sexually transmitted infections, and other infectious conditions; lenacapavir has been included in all DDI tables. New sections on alcohol use and patient-reported outcome measures (PROMs) have been included in the comorbidity panel, in addition to updates on many relevant topics, such as new resource guidance for deprescribing in people with HIV. Other sections, including travel, cognitive impairment, cancer screening, sexual health, and diabetes have also been revised extensively. The algorithm for the management of acute hepatitis C virus infection has been removed, as current guidelines recommend immediate treatment of all people with recently acquired hepatitis C virus. Updates on vaccination for hepatitis B virus and recommendations for simplification to tenofovir-free two-drug regimens in people with isolated anti-hepatitis B core antibodies are provided. In the opportunistic infections and COVID-19 panel, guidance on the management of COVID-19 in people with HIV has been updated according to the most up-to-date evidence, and a new section on monkeypox has been added.Conclusions In 2023, the EACS guidelines were updated extensively and now include several new sections. The recommendations are available as a free app, in interactive web format, and as a pdf online.

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023 / Ambrosioni, Juan; Levi, Laura; Alagaratnam, Jasmini; Van Bremen, Kathrin; Mastrangelo, Andrea; Waalewijn, Hylke; Molina, Jean-Michel; Guaraldi, Giovanni; Winston, Alan; Boesecke, Christoph; Cinque, Paola; Bamford, Alasdair; Calmy, Alexandra; Marzolini, Catia; Martínez, Esteban; Oprea, Cristiana; Welch, Steven; Koval, Anna; Mendao, Luis; Rockstroh, Jürgen K. - In: HIV MEDICINE. - ISSN 1464-2662. - 24:11(2023), pp. 1126-1136. [10.1111/hiv.13542]

Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023

Guaraldi, Giovanni;
2023

Abstract

Background The European AIDS Clinical Society (EACS) guidelines were revised in 2023 for the 19th time, and all aspects of HIV care were updated.Key Points of the Guidelines Update Version 12.0 of the guidelines recommend the same six first-line treatment options for antiretroviral treatment (ART)-naive adults as versions 11.0 and 11.1: tenofovir-based backbone plus an unboosted integrase inhibitor or doravirine; abacavir/lamivudine plus dolutegravir; or dual therapy with lamivudine or emtricitabine plus dolutegravir. The long-acting section has been expanded in the ART and drug-drug interaction (DDI) panels. Tables for preferred and alternative ART in children and adolescents have been updated, as has the section on prevention of vertical transmission, particularly with new guidance for breastfeeding. A new DDI table has been included for the ART and anti-infective drugs used for opportunistic infections, sexually transmitted infections, and other infectious conditions; lenacapavir has been included in all DDI tables. New sections on alcohol use and patient-reported outcome measures (PROMs) have been included in the comorbidity panel, in addition to updates on many relevant topics, such as new resource guidance for deprescribing in people with HIV. Other sections, including travel, cognitive impairment, cancer screening, sexual health, and diabetes have also been revised extensively. The algorithm for the management of acute hepatitis C virus infection has been removed, as current guidelines recommend immediate treatment of all people with recently acquired hepatitis C virus. Updates on vaccination for hepatitis B virus and recommendations for simplification to tenofovir-free two-drug regimens in people with isolated anti-hepatitis B core antibodies are provided. In the opportunistic infections and COVID-19 panel, guidance on the management of COVID-19 in people with HIV has been updated according to the most up-to-date evidence, and a new section on monkeypox has been added.Conclusions In 2023, the EACS guidelines were updated extensively and now include several new sections. The recommendations are available as a free app, in interactive web format, and as a pdf online.
2023
24
11
1126
1136
Major revision version 12.0 of the European AIDS Clinical Society guidelines 2023 / Ambrosioni, Juan; Levi, Laura; Alagaratnam, Jasmini; Van Bremen, Kathrin; Mastrangelo, Andrea; Waalewijn, Hylke; Molina, Jean-Michel; Guaraldi, Giovanni; Winston, Alan; Boesecke, Christoph; Cinque, Paola; Bamford, Alasdair; Calmy, Alexandra; Marzolini, Catia; Martínez, Esteban; Oprea, Cristiana; Welch, Steven; Koval, Anna; Mendao, Luis; Rockstroh, Jürgen K. - In: HIV MEDICINE. - ISSN 1464-2662. - 24:11(2023), pp. 1126-1136. [10.1111/hiv.13542]
Ambrosioni, Juan; Levi, Laura; Alagaratnam, Jasmini; Van Bremen, Kathrin; Mastrangelo, Andrea; Waalewijn, Hylke; Molina, Jean-Michel; Guaraldi, Giovan...espandi
File in questo prodotto:
File Dimensione Formato  
HIV Medicine - 2023 - Ambrosioni - Major revision version 12 0 of the European AIDS Clinical Society guidelines 2023.pdf

Open access

Tipologia: Versione pubblicata dall'editore
Dimensione 513.18 kB
Formato Adobe PDF
513.18 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1329596
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 22
social impact