Background: The study aimed to develop a model and build a nomogram to predict the probability of drug resistance in people with post-stroke epilepsy (PSE). Methods: Subjects with epilepsy secondary to ischemic stroke or spontaneous intracerebral hemorrhage were included. The study outcome was the occurrence of drug-resistant epilepsy defined according to International League Against Epilepsy criteria. Results: One hundred and sixty-four subjects with PSE were included and 32 (19.5%) were found to be drug-resistant. Five variables were identified as independent predictors of drug resistance and were included in the nomogram: age at stroke onset (odds ratio (OR): 0.941, 95% confidence interval (CI) 0.907–0.977), intracerebral hemorrhage (OR: 6.292, 95% CI 1.957–20.233), severe stroke (OR: 4.727, 95% CI 1.573–14.203), latency of PSE (>12 months, reference; 7–12 months, OR: 4.509, 95% CI 1.335–15.228; 0–6 months, OR: 99.099, 95% CI 14.873–660.272), and status epilepticus at epilepsy onset (OR: 14.127, 95% CI 2.540–78.564). The area under the receiver operating characteristic curve of the nomogram was 0.893 (95% CI: 0.832–0.956). Conclusions: Great variability exists in the risk of drug resistance in people with PSE. A nomogram based on a set of readily available clinical variables may represent a practical tool for an individualized prediction of drug-resistant PSE.

Individualized Prediction of Drug Resistance in People with Post-Stroke Epilepsy: A Retrospective Study / Lattanzi, S.; Meletti, S.; Trinka, E.; Brigo, F.; Turcato, G.; Rinaldi, C.; Cagnetti, C.; Foschi, N.; Broggi, S.; Norata, D.; Silvestrini, M.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 12:11(2023), pp. N/A-N/A. [10.3390/jcm12113610]

Individualized Prediction of Drug Resistance in People with Post-Stroke Epilepsy: A Retrospective Study

Meletti S.;
2023

Abstract

Background: The study aimed to develop a model and build a nomogram to predict the probability of drug resistance in people with post-stroke epilepsy (PSE). Methods: Subjects with epilepsy secondary to ischemic stroke or spontaneous intracerebral hemorrhage were included. The study outcome was the occurrence of drug-resistant epilepsy defined according to International League Against Epilepsy criteria. Results: One hundred and sixty-four subjects with PSE were included and 32 (19.5%) were found to be drug-resistant. Five variables were identified as independent predictors of drug resistance and were included in the nomogram: age at stroke onset (odds ratio (OR): 0.941, 95% confidence interval (CI) 0.907–0.977), intracerebral hemorrhage (OR: 6.292, 95% CI 1.957–20.233), severe stroke (OR: 4.727, 95% CI 1.573–14.203), latency of PSE (>12 months, reference; 7–12 months, OR: 4.509, 95% CI 1.335–15.228; 0–6 months, OR: 99.099, 95% CI 14.873–660.272), and status epilepticus at epilepsy onset (OR: 14.127, 95% CI 2.540–78.564). The area under the receiver operating characteristic curve of the nomogram was 0.893 (95% CI: 0.832–0.956). Conclusions: Great variability exists in the risk of drug resistance in people with PSE. A nomogram based on a set of readily available clinical variables may represent a practical tool for an individualized prediction of drug-resistant PSE.
2023
12
11
N/A
N/A
Individualized Prediction of Drug Resistance in People with Post-Stroke Epilepsy: A Retrospective Study / Lattanzi, S.; Meletti, S.; Trinka, E.; Brigo, F.; Turcato, G.; Rinaldi, C.; Cagnetti, C.; Foschi, N.; Broggi, S.; Norata, D.; Silvestrini, M.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 12:11(2023), pp. N/A-N/A. [10.3390/jcm12113610]
Lattanzi, S.; Meletti, S.; Trinka, E.; Brigo, F.; Turcato, G.; Rinaldi, C.; Cagnetti, C.; Foschi, N.; Broggi, S.; Norata, D.; Silvestrini, M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1319913
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