Different strategies have been proposed to target neoangiogenesis in gliomas, besides those targeting Vascular Endothelial Growth Factor (VEGF). The chemokine Interleukin-8 (IL-8) has been shown to possess both tumorigenic and proangiogenic properties. Although different pathways of induction of IL-8 gene expression have been already elucidated, few data are available on its post-transcriptional regulation in gliomas.
Regulation of IL-8 gene expression in gliomas by microRNA miR-93 / Fabbri, Enrica; Brognara, Eleonora; Montagner, Giulia; Ghimenton, Claudio; Eccher, Albino; Cantù, Cinzia; Khalil, Susanna; Bezzerri, Valentino; Provezza, Lisa; Bianchi, Nicoletta; Finotti, Alessia; Borgatti, Monica; Moretto, Giuseppe; Chilosi, Marco; Cabrini, Giulio; Gambari, Roberto. - In: BMC CANCER. - ISSN 1471-2407. - 15:1(2015), pp. 661-661. [10.1186/s12885-015-1659-1]
Regulation of IL-8 gene expression in gliomas by microRNA miR-93
ECCHER, Albino;
2015
Abstract
Different strategies have been proposed to target neoangiogenesis in gliomas, besides those targeting Vascular Endothelial Growth Factor (VEGF). The chemokine Interleukin-8 (IL-8) has been shown to possess both tumorigenic and proangiogenic properties. Although different pathways of induction of IL-8 gene expression have been already elucidated, few data are available on its post-transcriptional regulation in gliomas.
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