Solid-state nanopore-based sensors are promising platforms for next-generation sequencing technologies, featuring label-free single-molecule sensitivity, rapid detection, and low-cost manufacturing. In recent years, solid-state nanopores have been explored due to their miscellaneous fabrication methods and their use in a wide range of sensing applications. Here, we highlight a novel family of solid-state nanopores which have recently appeared, namely plasmonic nanopores. The use of plasmonic nanopores to engineer electromagnetic fields around a nanopore sensor allows for enhanced optical spectroscopies, local control over temperature, thermophoresis of molecules and ions to/from the sensor, and trapping of entities. This Mini Review offers a comprehensive understanding of the current state-of-the-art plasmonic nano pores for single-molecule detection and biomolecular sequencing applications and discusses the latest advances and future perspectives on plasmonic nano-porebased technologies.

Plasmonic Nanopores for Single-Molecule Detection and Manipulation: Toward Sequencing Applications / Garoli, D; Yamazaki, H; Maccaferri, N; Wanunu, M. - In: NANO LETTERS. - ISSN 1530-6984. - 19:11(2019), pp. 7553-7562. [10.1021/acs.nanolett.9b02759]

Plasmonic Nanopores for Single-Molecule Detection and Manipulation: Toward Sequencing Applications

Garoli D;
2019

Abstract

Solid-state nanopore-based sensors are promising platforms for next-generation sequencing technologies, featuring label-free single-molecule sensitivity, rapid detection, and low-cost manufacturing. In recent years, solid-state nanopores have been explored due to their miscellaneous fabrication methods and their use in a wide range of sensing applications. Here, we highlight a novel family of solid-state nanopores which have recently appeared, namely plasmonic nanopores. The use of plasmonic nanopores to engineer electromagnetic fields around a nanopore sensor allows for enhanced optical spectroscopies, local control over temperature, thermophoresis of molecules and ions to/from the sensor, and trapping of entities. This Mini Review offers a comprehensive understanding of the current state-of-the-art plasmonic nano pores for single-molecule detection and biomolecular sequencing applications and discusses the latest advances and future perspectives on plasmonic nano-porebased technologies.
2019
19
11
7553
7562
Plasmonic Nanopores for Single-Molecule Detection and Manipulation: Toward Sequencing Applications / Garoli, D; Yamazaki, H; Maccaferri, N; Wanunu, M. - In: NANO LETTERS. - ISSN 1530-6984. - 19:11(2019), pp. 7553-7562. [10.1021/acs.nanolett.9b02759]
Garoli, D; Yamazaki, H; Maccaferri, N; Wanunu, M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1315918
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