: Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the most commonly used regimen for the upfront treatment of diffuse large B-cell lymphoma (DLBCL). However, it is associated with cardiotoxicity, especially in older patients. Substituting doxorubicin with non-PEGylated liposomal doxorubicin (R-COMP) may reduce the risk of cardiac events, but its efficacy has never been demonstrated in prospective trials. We describe the characteristics and outcome of patients with DLBCL aged ≥65 years prospectively enrolled in the Elderly Project by the Fondazione Italiana Linfomi and treated with full doses of R-CHOP or R-COMP per local practice. Starting from 1163 patients, 383 (55%) were treated with R-CHOP and 308 (45%) with R-COMP. Patients treated with R-COMP were older (median age, 76 vs 71 years), less frequently fit at simplified geriatric assessment (61% vs 88%; P < .001), and had a more frequent baseline cardiac disorders (grade >1, 32% vs 8%; P < .001). Three-year progression-free survival (PFS) was similar between R-CHOP and R-COMP (70% and 64%); 3-year overall survival was 77%, and 71% respectively. R-CHOP was associated with better PFS vs R-COMP only in the Elderly Prognostic Index (EPI) low-risk group. The two groups had similar rates of treatment interruptions due to toxicities or of cardiac events (P = 1.00). We suggest R-COMP is a potentially curative treatment for older patients with intermediate- or high-risk EPI, even in the presence of a baseline cardiopathy. R-CHOP is confirmed as the standard therapy for low risk patients.

A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma / Arcari, Annalisa; Rigacci, Lugi; Tucci, Alessandra; Puccini, Benedetta; Usai, Sara Veronica; Cavallo, Federica; Fabbri, Alberto; Balzarotti, Monica; Pelliccia, Sabrina; Luminari, Stefano; Pennese, Elsa; Zilioli, Vittorio Ruggero; Mahmoud, Abdurraouf Mokhtar; Musuraca, Gerardo; Marino, Dario; Sartori, Roberto; Botto, Barbara; Gini, Guido; Zanni, Manuela; Hohaus, Stefan; Tarantini, Giuseppe; Flenghi, Leonardo; Tani, Monica; Di Rocco, Alice; Merli, Michele; Vallisa, Daniele; Pagani, Chiara; Nassi, Luca; Dessì, Daniela; Ferrero, Simone; Cencini, Emanuele; Bernuzzi, Patrizia; Mammi, Caterina; Marcheselli, Luigi; Tabanelli, Valentina; Spina, Michele; Merli, Francesco. - In: BLOOD ADVANCES. - ISSN 2473-9529. - 7:15(2023), pp. 4160-4169. [10.1182/bloodadvances.2023009839]

A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma

Luminari, Stefano
Writing – Review & Editing
;
Mammi, Caterina;Marcheselli, Luigi;
2023

Abstract

: Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is the most commonly used regimen for the upfront treatment of diffuse large B-cell lymphoma (DLBCL). However, it is associated with cardiotoxicity, especially in older patients. Substituting doxorubicin with non-PEGylated liposomal doxorubicin (R-COMP) may reduce the risk of cardiac events, but its efficacy has never been demonstrated in prospective trials. We describe the characteristics and outcome of patients with DLBCL aged ≥65 years prospectively enrolled in the Elderly Project by the Fondazione Italiana Linfomi and treated with full doses of R-CHOP or R-COMP per local practice. Starting from 1163 patients, 383 (55%) were treated with R-CHOP and 308 (45%) with R-COMP. Patients treated with R-COMP were older (median age, 76 vs 71 years), less frequently fit at simplified geriatric assessment (61% vs 88%; P < .001), and had a more frequent baseline cardiac disorders (grade >1, 32% vs 8%; P < .001). Three-year progression-free survival (PFS) was similar between R-CHOP and R-COMP (70% and 64%); 3-year overall survival was 77%, and 71% respectively. R-CHOP was associated with better PFS vs R-COMP only in the Elderly Prognostic Index (EPI) low-risk group. The two groups had similar rates of treatment interruptions due to toxicities or of cardiac events (P = 1.00). We suggest R-COMP is a potentially curative treatment for older patients with intermediate- or high-risk EPI, even in the presence of a baseline cardiopathy. R-CHOP is confirmed as the standard therapy for low risk patients.
2023
2023
7
15
4160
4169
A Fondazione Italiana Linfomi cohort study of R-COMP vs R-CHOP in older patients with diffuse large B-cell lymphoma / Arcari, Annalisa; Rigacci, Lugi; Tucci, Alessandra; Puccini, Benedetta; Usai, Sara Veronica; Cavallo, Federica; Fabbri, Alberto; Balzarotti, Monica; Pelliccia, Sabrina; Luminari, Stefano; Pennese, Elsa; Zilioli, Vittorio Ruggero; Mahmoud, Abdurraouf Mokhtar; Musuraca, Gerardo; Marino, Dario; Sartori, Roberto; Botto, Barbara; Gini, Guido; Zanni, Manuela; Hohaus, Stefan; Tarantini, Giuseppe; Flenghi, Leonardo; Tani, Monica; Di Rocco, Alice; Merli, Michele; Vallisa, Daniele; Pagani, Chiara; Nassi, Luca; Dessì, Daniela; Ferrero, Simone; Cencini, Emanuele; Bernuzzi, Patrizia; Mammi, Caterina; Marcheselli, Luigi; Tabanelli, Valentina; Spina, Michele; Merli, Francesco. - In: BLOOD ADVANCES. - ISSN 2473-9529. - 7:15(2023), pp. 4160-4169. [10.1182/bloodadvances.2023009839]
Arcari, Annalisa; Rigacci, Lugi; Tucci, Alessandra; Puccini, Benedetta; Usai, Sara Veronica; Cavallo, Federica; Fabbri, Alberto; Balzarotti, Monica; Pelliccia, Sabrina; Luminari, Stefano; Pennese, Elsa; Zilioli, Vittorio Ruggero; Mahmoud, Abdurraouf Mokhtar; Musuraca, Gerardo; Marino, Dario; Sartori, Roberto; Botto, Barbara; Gini, Guido; Zanni, Manuela; Hohaus, Stefan; Tarantini, Giuseppe; Flenghi, Leonardo; Tani, Monica; Di Rocco, Alice; Merli, Michele; Vallisa, Daniele; Pagani, Chiara; Nassi, Luca; Dessì, Daniela; Ferrero, Simone; Cencini, Emanuele; Bernuzzi, Patrizia; Mammi, Caterina; Marcheselli, Luigi; Tabanelli, Valentina; Spina, Michele; Merli, Francesco
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