OBJECTIVE - To investigate the prevalence of maturity-onset diabetes of the young (MODY) in Italian children with incidental hyperglycemia. RESEARCH DESIGN AND METHODS - Among 748 subjects age 1-18 years with incidental hyperglycemia, minimal diagnostic criteria for MODY were met by 172 families. Mutational analyses of the glucokinase (GCK) and hepatocyte nuclear factor 1α (HNF1A) genes were performed. RESULTS - We identified 85 GCK gene mutations in 109 probands and 10 HNF1A mutations in 12 probands. In GCK patients, the median neonatal weight and age at the first evaluation were lower than those found in patients with HNF1A mutations. Median fasting plasma glucose and impaired fasting glucose/impaired glucose tolerance frequency after oral glucose tolerance testing were higher in GCK patients, who also showed a lower frequency of diabetes than HNF1A patients. CONCLUSIONS - GCK mutations are the prevailing cause of MODY (63.4%) when the index case is recruited in Italian children with incidental hyperglycemia. © 2009 by the American Diabetes Association.

Maturity-onset diabetes of the young in children with incidental hyperglycemia: A multicenter Italian study of 172 families / Lorini, R.; Klersy, C.; D'Annunzio, G.; Massa, O.; Minuto, N.; Iafusco, D.; Bellanne-Chantelot, C.; Frongia, A. P.; Toni, S.; Meschi, F.; Cerutti, F.; Barbetti, F.; Banin, P.; Cadario, F.; Calisti, L.; Cappa, M.; Crino, A.; Cherubini, V.; Chiari, G.; Vanelli, M.; Cotellessa, M.; D'Amato, E.; Cauvin, V.; Franzese, A.; Guazzarotti, L.; Iughetti, L.; Mancabitti, M. L.; Meossi, C.; Pinelli, L.; Pocecco, M.; Scaramuzza, A.; Sulli, N.; Visentin, A.. - In: DIABETES CARE. - ISSN 0149-5992. - 32:10(2009), pp. 1864-1866. [10.2337/dc08-2018]

Maturity-onset diabetes of the young in children with incidental hyperglycemia: A multicenter Italian study of 172 families

Iughetti L.;
2009

Abstract

OBJECTIVE - To investigate the prevalence of maturity-onset diabetes of the young (MODY) in Italian children with incidental hyperglycemia. RESEARCH DESIGN AND METHODS - Among 748 subjects age 1-18 years with incidental hyperglycemia, minimal diagnostic criteria for MODY were met by 172 families. Mutational analyses of the glucokinase (GCK) and hepatocyte nuclear factor 1α (HNF1A) genes were performed. RESULTS - We identified 85 GCK gene mutations in 109 probands and 10 HNF1A mutations in 12 probands. In GCK patients, the median neonatal weight and age at the first evaluation were lower than those found in patients with HNF1A mutations. Median fasting plasma glucose and impaired fasting glucose/impaired glucose tolerance frequency after oral glucose tolerance testing were higher in GCK patients, who also showed a lower frequency of diabetes than HNF1A patients. CONCLUSIONS - GCK mutations are the prevailing cause of MODY (63.4%) when the index case is recruited in Italian children with incidental hyperglycemia. © 2009 by the American Diabetes Association.
2009
32
10
1864
1866
Maturity-onset diabetes of the young in children with incidental hyperglycemia: A multicenter Italian study of 172 families / Lorini, R.; Klersy, C.; D'Annunzio, G.; Massa, O.; Minuto, N.; Iafusco, D.; Bellanne-Chantelot, C.; Frongia, A. P.; Toni, S.; Meschi, F.; Cerutti, F.; Barbetti, F.; Banin, P.; Cadario, F.; Calisti, L.; Cappa, M.; Crino, A.; Cherubini, V.; Chiari, G.; Vanelli, M.; Cotellessa, M.; D'Amato, E.; Cauvin, V.; Franzese, A.; Guazzarotti, L.; Iughetti, L.; Mancabitti, M. L.; Meossi, C.; Pinelli, L.; Pocecco, M.; Scaramuzza, A.; Sulli, N.; Visentin, A.. - In: DIABETES CARE. - ISSN 0149-5992. - 32:10(2009), pp. 1864-1866. [10.2337/dc08-2018]
Lorini, R.; Klersy, C.; D'Annunzio, G.; Massa, O.; Minuto, N.; Iafusco, D.; Bellanne-Chantelot, C.; Frongia, A. P.; Toni, S.; Meschi, F.; Cerutti, F.;...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1313566
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