Objectives: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy.Methods: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The ref-erence was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used.Results: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P < 0.0 0 01) and that of anti-hepatitis D virus (HDV) remained stable (9.3% vs 8.3%). In both cohorts, about 25% of the patients had cirrhosis, and those in the PITER cohort were older. HBeAg-positive was 5.0% vs 12.6% ( P < 0.0 0 01) and anti-HDV positive 24.8% vs 17.5% ( P < 0.0017). In the logistic model, the variables associated with cirrhosis were anti-HDV-positive (odds ratio = 10.08; confidence interval 7.63-13.43), age, sex, and body mass index; the likelihood of cirrhosis was reduced by 40% in the PITER cohort. Among non-Italians, 12.3% were HBeAg-positive (vs 23.4% in the MASTER cohort; P < 0.0 0 01), and 12.3% were anti-HDV-positive (vs 11.1%). Overall, the adherence to the European Association for the Study of the Liver recommendations for antiviral treatment increased over time.Conclusion: Chronic hepatitis B virus infection appears to be in the process of becoming under control in Italy; however, HDV infection is still a health concern in patients with cirrhosis and in migrants.(c) 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination / Brancaccio, G.; Coco, B.; Nardi, A.; Quaranta, M. G.; Tosti, M. E.; Ferrigno, L.; Cacciola, I.; Messina, V.; Chessa, L.; Morisco, F.; Milella, M.; Barbaro, F.; Ciancio, A.; Russo, F. P.; Coppola, N.; Blanc, P.; Claar, E.; Verucchi, G.; Puoti, M.; Zignego, A. L.; Chemello, L.; Madonia, S.; Fagiuoli, S.; Marzano, A.; Ferrari, C.; Lampertico, P.; Di Marco, V.; Craxì, A.; Santantonio, T. A.; Raimondo, G.; Brunetto, M. R.; Gaeta, G. B.; Kondili, L. A.; Pasulo, L.; Coppola, C.; Pisano, F.; Romano, M.; Porcu, C.; Bottalico, I. F.; Cossiga, V.; Tata, X.; Sagnelli, C.; Pierotti, P.; Degasperi, E.; Rosato, V.; Badia, L.; Ieluzzi, D.; Monti, M.; Bavetta, M. G.; Cavalletto, L.; Toniutto, P.; Fornasiere, E.; Colecchia, A.; Ferrarese, A.; Nardone, G.; Rocco, A.; Viganò, M.; Foschi, F. G.; Conti, F.; Morsica, G.; Salpietro, S.; Torti, C.; Costa, C.; Federico, A.; Dallio, M.; Giorgini, A.; Anselmo, M.; De Leo, P.; Zaltron, S.; Cambianica, A.; Piscaglia, F.; Serio, I.; Schivazappa, S.; Mastroianni, A.; Chidichimo, L.; Massari, M.; Mazzaro, C.; Marrone, A.; D'Amore, F. M.; D'Offizi, G.; Licata, A.; Niro, G. A.; Pollicino, T.; Aghemo, A.. - In: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. - ISSN 1201-9712. - 129:(2023), pp. 266-273. [10.1016/j.ijid.2023.02.006]
Trends in chronic hepatitis B virus infection in Italy over a 10-year period: Clues from the nationwide PITER and MASTER cohorts toward elimination
Brancaccio G.;Nardi A.;Marzano A.;Di Marco V.;Raimondo G.;Coppola C.;Colecchia A.;Massari M.;
2023
Abstract
Objectives: The study measures trends in the profile of patients with chronic hepatitis B virus linked to care in Italy.Methods: A cross-sectional, multicenter, observational cohort (PITER cohort) of consecutive patients with hepatitis B surface antigen (HBsAg) over the period 2019-2021 from 46 centers was evaluated. The ref-erence was the MASTER cohort collected over the years 2012-2015. Standard statistical methods were used.Results: The PITER cohort enrolled 4583 patients, of whom 21.8% were non-Italian natives. Compared with those in MASTER, the patients were older and more often female. The prevalence of hepatitis B e antigen (HBeAg) declined (7.2% vs 12.3; P < 0.0 0 01) and that of anti-hepatitis D virus (HDV) remained stable (9.3% vs 8.3%). In both cohorts, about 25% of the patients had cirrhosis, and those in the PITER cohort were older. HBeAg-positive was 5.0% vs 12.6% ( P < 0.0 0 01) and anti-HDV positive 24.8% vs 17.5% ( P < 0.0017). In the logistic model, the variables associated with cirrhosis were anti-HDV-positive (odds ratio = 10.08; confidence interval 7.63-13.43), age, sex, and body mass index; the likelihood of cirrhosis was reduced by 40% in the PITER cohort. Among non-Italians, 12.3% were HBeAg-positive (vs 23.4% in the MASTER cohort; P < 0.0 0 01), and 12.3% were anti-HDV-positive (vs 11.1%). Overall, the adherence to the European Association for the Study of the Liver recommendations for antiviral treatment increased over time.Conclusion: Chronic hepatitis B virus infection appears to be in the process of becoming under control in Italy; however, HDV infection is still a health concern in patients with cirrhosis and in migrants.(c) 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
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