Background and objective: Although the efficacy of SARS-CoV-2 vaccines in preventing severe disease – especially in older adults – is widely demonstrated, there are not many studies conducted in the Alps with large sample sizes and during Omicron variant period. Moreover, scarce literature analyses the hospitalisation length of SARS-CoV-2 patients and its association with vaccination status. Aim of this study is to investigate the associations between ordinary or intensive care unit (ICU) hospitalisations and the vaccination status of SARS-CoV2 adult patients resident in the Italian alpine province of Bolzano. Methods: We collected anonymized data from 93643 patients who swabbed positive for SARS-CoV-2 between November‘21 and February’22 – coinciding with the arrival of the Omicron variant. Associations between vaccination status and hospitalisation characteristics were assessed using bivariate statistics and multiple logistic regression. Results: Of 93643 positive patients, 925 were hospitalised (90% ordinary ward, 10% ICU). Among over 65 (8% of the sample and 68% of hospitalisations), vaccinated patients had a significantly lower risk of being admitted to ordinary wards compared to not vaccinated: Odds Ratio(OR)=0.40(CI:0.35-0.48); to ICU: OR=0.26(CI:0.15-0.47) and to die: OR=0.39(CI:0.29-0.52). These risks were even lower for vaccinated with booster compared to unvaccinated. Suggestively, also among vaccinated patients those with booster showed decreased risk of hospitalisation: OR=0.54(CI:0.42-0.67); and death: OR=0.39(CI:0.25-0.61). Similar associations were found in age range 30-65. Finally, average duration of ICU stay was significantly longer for unvaccinated people compared to vaccinated (9-6 days; p<0.003), especially in over 65 (11-6 days; p<0.05). Conclusion: Results suggest that vaccination played a protective role against severe disease, even during Omicron variant period and especially in the most at-risk age groups. Additional/booster dose have granted a greater protection compared to the primary cycle, supporting its administration policy. The shorter ICU stay of vaccinated people suggests that vaccination could have made recovery faster

Effectiveness of vaccination on hospitalisation related outcomes: a population-cased study in Northern Italy / Lorenzon, Antonio; Palandri, Lucia; Cristofor, Catalina; Lozza, Filippo; Uguzzoni, Francesco; Rizzi, Cristiana; Poluzzi, Riccardo; Scasserra, Maria; Bertoli, Pierpaolo; Zerzer, Florian; Righi, Elena. - In: POPULATION MEDICINE. - ISSN 2654-1459. - 5:Supplement(2023), pp. 159-159. (Intervento presentato al convegno 17th World Congress on Public Health tenutosi a Rome nel 2-6 May 2023) [10.18332/popmed/164429].

Effectiveness of vaccination on hospitalisation related outcomes: a population-cased study in Northern Italy

Lorenzon, Antonio;Palandri, Lucia;Uguzzoni, Francesco;Rizzi, Cristiana;Scasserra, Maria;Righi, Elena
2023

Abstract

Background and objective: Although the efficacy of SARS-CoV-2 vaccines in preventing severe disease – especially in older adults – is widely demonstrated, there are not many studies conducted in the Alps with large sample sizes and during Omicron variant period. Moreover, scarce literature analyses the hospitalisation length of SARS-CoV-2 patients and its association with vaccination status. Aim of this study is to investigate the associations between ordinary or intensive care unit (ICU) hospitalisations and the vaccination status of SARS-CoV2 adult patients resident in the Italian alpine province of Bolzano. Methods: We collected anonymized data from 93643 patients who swabbed positive for SARS-CoV-2 between November‘21 and February’22 – coinciding with the arrival of the Omicron variant. Associations between vaccination status and hospitalisation characteristics were assessed using bivariate statistics and multiple logistic regression. Results: Of 93643 positive patients, 925 were hospitalised (90% ordinary ward, 10% ICU). Among over 65 (8% of the sample and 68% of hospitalisations), vaccinated patients had a significantly lower risk of being admitted to ordinary wards compared to not vaccinated: Odds Ratio(OR)=0.40(CI:0.35-0.48); to ICU: OR=0.26(CI:0.15-0.47) and to die: OR=0.39(CI:0.29-0.52). These risks were even lower for vaccinated with booster compared to unvaccinated. Suggestively, also among vaccinated patients those with booster showed decreased risk of hospitalisation: OR=0.54(CI:0.42-0.67); and death: OR=0.39(CI:0.25-0.61). Similar associations were found in age range 30-65. Finally, average duration of ICU stay was significantly longer for unvaccinated people compared to vaccinated (9-6 days; p<0.003), especially in over 65 (11-6 days; p<0.05). Conclusion: Results suggest that vaccination played a protective role against severe disease, even during Omicron variant period and especially in the most at-risk age groups. Additional/booster dose have granted a greater protection compared to the primary cycle, supporting its administration policy. The shorter ICU stay of vaccinated people suggests that vaccination could have made recovery faster
2023
5
159
159
Lorenzon, Antonio; Palandri, Lucia; Cristofor, Catalina; Lozza, Filippo; Uguzzoni, Francesco; Rizzi, Cristiana; Poluzzi, Riccardo; Scasserra, Maria; B...espandi
Effectiveness of vaccination on hospitalisation related outcomes: a population-cased study in Northern Italy / Lorenzon, Antonio; Palandri, Lucia; Cristofor, Catalina; Lozza, Filippo; Uguzzoni, Francesco; Rizzi, Cristiana; Poluzzi, Riccardo; Scasserra, Maria; Bertoli, Pierpaolo; Zerzer, Florian; Righi, Elena. - In: POPULATION MEDICINE. - ISSN 2654-1459. - 5:Supplement(2023), pp. 159-159. (Intervento presentato al convegno 17th World Congress on Public Health tenutosi a Rome nel 2-6 May 2023) [10.18332/popmed/164429].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1308387
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