Purpose of review: COVID-19 pandemic has caused more than 6.6 million deaths globally. Tremendous efforts have been committed for the development of new and repurposed drugs for the treatment of COVID-19. Although different international and national guidelines share consensus in the management of COVID-19 disease with different levels of severity, new challenges have emerged, steering the need for ongoing research in advancing the clinical management of COVID-19. Recent findings: This review focuses on recent data from randomized trials and postmarketing real-world evidence for the treatment of mild to moderate disease in the outpatient setting and patients hospitalized for COVID-19 with varying level of severity. Relevant data for treatment of the latest omicron sub-variants in people who received vaccination are presented. Challenges in special populations, including immunocompromised hosts, patients with renal failure and pregnant women, are also discussed. Summary: Treatment of COVID-19 should be personalized according to host characteristics, degree of severity and available treatment options.
Drug treatment of COVID-19 infection / Lui, Grace; Guaraldi, Giovanni. - In: CURRENT OPINION IN PULMONARY MEDICINE. - ISSN 1070-5287. - 29:3(2023), pp. 174-183. [10.1097/MCP.0000000000000953]
Drug treatment of COVID-19 infection
Guaraldi, Giovanni
2023
Abstract
Purpose of review: COVID-19 pandemic has caused more than 6.6 million deaths globally. Tremendous efforts have been committed for the development of new and repurposed drugs for the treatment of COVID-19. Although different international and national guidelines share consensus in the management of COVID-19 disease with different levels of severity, new challenges have emerged, steering the need for ongoing research in advancing the clinical management of COVID-19. Recent findings: This review focuses on recent data from randomized trials and postmarketing real-world evidence for the treatment of mild to moderate disease in the outpatient setting and patients hospitalized for COVID-19 with varying level of severity. Relevant data for treatment of the latest omicron sub-variants in people who received vaccination are presented. Challenges in special populations, including immunocompromised hosts, patients with renal failure and pregnant women, are also discussed. Summary: Treatment of COVID-19 should be personalized according to host characteristics, degree of severity and available treatment options.Pubblicazioni consigliate
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