Introduction There are limited data on the effects of COVID-19 on peritoneal dialysis (PD) patients. This study aimed to describe the impact of COVID-19 on the PD population. Methods A monocentric retrospective observational study was conducted on 146 consecutive PD patients followed from January 2020 to March 2022 at the University Hospital of Modena, Italy. Results Twenty-seven (18.4%) PD patients experienced 29 episodes of SARS-CoV-2 infection, corresponding to an incidence rate of 0.16 episodes/patient-year. Median age of COVID-19 patients was 60.4 (interquartile range [IQR] 50.2-66.5) years. In unvaccinated patients (n. 9), COVID-19 was always symptomatic and manifested with fever (100%) and cough (77.7%). COVID-19 caused hospital admission of three (33.3%) patients and two (22.2%) died of septic shock. COVID-19 was symptomatic in 83.3% of vaccinated subjects (n.18) and manifested with fever (61.1%) and cough (55.6%). Hospital admission occurred in 27.8% of the subjects but all were discharged home. Median SARS-CoV-2 shedding was 32 and 26 days in the unvaccinated and vaccinated groups, respectively. At the end of the follow-up, COVID-19 triggered the shift from PD to HD in two subjects without affecting the residual renal function of the remaining patients. Overall, COVID-19 caused an excess death of 22.2%. COVID-19 vaccination refusal accounted for only 1.6% in this cohort of patients. Conclusion COVID-19 incident rate was 0.16 episodes/patient-year in the PD population. About one-third of the patients were hospitalized for severe infection. Fatal outcome occurred in two (7.4%) unvaccinated patients. A low vaccination refusal rate was observed in this population.

Prevalence, clinical course and outcomes of COVID-19 in peritoneal dialysis (PD) patients: a single-center experience / Alfano, Gaetano; Fontana, Francesco; Giovanella, Silvia; Morisi, Niccolo; Amurri, Alessio; Ligabue, Giulia; Guaraldi, Giovanni; Ferrari, Annachiara; Cappelli, Gianni; Magistroni, Riccardo; Gregorini, Mariacristina; Donati, Gabriele. - In: CLINICAL AND EXPERIMENTAL NEPHROLOGY. - ISSN 1342-1751. - 27:2(2023), pp. 171-178. [10.1007/s10157-022-02283-0]

Prevalence, clinical course and outcomes of COVID-19 in peritoneal dialysis (PD) patients: a single-center experience

Alfano, Gaetano;Fontana, Francesco;Giovanella, Silvia;Morisi, Niccolo;Amurri, Alessio;Ligabue, Giulia;Guaraldi, Giovanni;Cappelli, Gianni;Magistroni, Riccardo;Donati, Gabriele
2023

Abstract

Introduction There are limited data on the effects of COVID-19 on peritoneal dialysis (PD) patients. This study aimed to describe the impact of COVID-19 on the PD population. Methods A monocentric retrospective observational study was conducted on 146 consecutive PD patients followed from January 2020 to March 2022 at the University Hospital of Modena, Italy. Results Twenty-seven (18.4%) PD patients experienced 29 episodes of SARS-CoV-2 infection, corresponding to an incidence rate of 0.16 episodes/patient-year. Median age of COVID-19 patients was 60.4 (interquartile range [IQR] 50.2-66.5) years. In unvaccinated patients (n. 9), COVID-19 was always symptomatic and manifested with fever (100%) and cough (77.7%). COVID-19 caused hospital admission of three (33.3%) patients and two (22.2%) died of septic shock. COVID-19 was symptomatic in 83.3% of vaccinated subjects (n.18) and manifested with fever (61.1%) and cough (55.6%). Hospital admission occurred in 27.8% of the subjects but all were discharged home. Median SARS-CoV-2 shedding was 32 and 26 days in the unvaccinated and vaccinated groups, respectively. At the end of the follow-up, COVID-19 triggered the shift from PD to HD in two subjects without affecting the residual renal function of the remaining patients. Overall, COVID-19 caused an excess death of 22.2%. COVID-19 vaccination refusal accounted for only 1.6% in this cohort of patients. Conclusion COVID-19 incident rate was 0.16 episodes/patient-year in the PD population. About one-third of the patients were hospitalized for severe infection. Fatal outcome occurred in two (7.4%) unvaccinated patients. A low vaccination refusal rate was observed in this population.
2023
3-nov-2022
27
2
171
178
Prevalence, clinical course and outcomes of COVID-19 in peritoneal dialysis (PD) patients: a single-center experience / Alfano, Gaetano; Fontana, Francesco; Giovanella, Silvia; Morisi, Niccolo; Amurri, Alessio; Ligabue, Giulia; Guaraldi, Giovanni; Ferrari, Annachiara; Cappelli, Gianni; Magistroni, Riccardo; Gregorini, Mariacristina; Donati, Gabriele. - In: CLINICAL AND EXPERIMENTAL NEPHROLOGY. - ISSN 1342-1751. - 27:2(2023), pp. 171-178. [10.1007/s10157-022-02283-0]
Alfano, Gaetano; Fontana, Francesco; Giovanella, Silvia; Morisi, Niccolo; Amurri, Alessio; Ligabue, Giulia; Guaraldi, Giovanni; Ferrari, Annachiara; Cappelli, Gianni; Magistroni, Riccardo; Gregorini, Mariacristina; Donati, Gabriele
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1295529
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