Infections are a major cause of morbidity and mortality among immune-compromised patients. The author discusses bacterial and mycotic infection prophylaxis in granulocytopenic patients with hematologic malignancies. Various strategies have been devised to prevent such infections including: combination oral antibacterial and antifungal prophylaxis with quinolones and newer azoles (fluconazole, itraconazole), high efficiency air filtration, protective isolation, and central venous catheter management. However, the emergence of antibiotic-resistant organisms continues to pose a major challenge to the successful eradication and prevention of infections in neutropenic hosts, and thus demands the development of innovative antibiotic approaches and infection control procedures.
Prevention of bacterial and mycotic infections in patients with hematological malignancies / Candoni, A.. - In: RIVISTA MEDICA DEL FRIULI. - ISSN 1124-139X. - 3:2(1997), pp. 75-79.