Transformation to acute myeloid leukemia (AML) is a known complication of myeloproliferative neoplasia (MPN). Recent studies reported the high incidence (53%) of JAK2 negative blasts from transformed JAK2V617F-MPN. We collected, by cell sorting, blast cells, and mature cells (GRA) from total bone marrow (BM) of 34 patients newly diagnosed of secondary AML. At MPN diagnosis (PMF n = 18; PV n = 9; ET n = 7), JAK2 was mutated in 22 of 34 patients. Twenty of 22 JAK2V617F-MPN (91%) maintained the mutation in blasts and GRA after leukemic switch, while in 2 of 22 patients the selected compartments lost the mutation. Surprisingly, we also found the first case of JAK2V617F-AML from a wild type (WT)-MPN. In contrast to the previous study, we conclude that JAK2V617F-MPN yields rarely (9%) a JAK2WT-AML and any JAK2-status modification/persistence involves always the entire BM during leukemic transformation.

JAK2V617F mutation persists in blasts and mature cells of transformed JAK2V617F-positive-myeloproliferative neoplasia: A European Leukemia Net (ENL) study / Rinaldi, C. R.; Rinaldi, P.; Gemei, M.; Grimaldi, F.; Battipaglia, G.; Vecchio, L. D.; Martino, B.; Specchia, G.; Candoni, A.; Gugliotta, L.; Vannucchi, A. M.; Barbui, T.; Pane, F.. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - 85:5(2010), pp. 383-386. [10.1002/ajh.21687]

JAK2V617F mutation persists in blasts and mature cells of transformed JAK2V617F-positive-myeloproliferative neoplasia: A European Leukemia Net (ENL) study

Candoni A.;
2010

Abstract

Transformation to acute myeloid leukemia (AML) is a known complication of myeloproliferative neoplasia (MPN). Recent studies reported the high incidence (53%) of JAK2 negative blasts from transformed JAK2V617F-MPN. We collected, by cell sorting, blast cells, and mature cells (GRA) from total bone marrow (BM) of 34 patients newly diagnosed of secondary AML. At MPN diagnosis (PMF n = 18; PV n = 9; ET n = 7), JAK2 was mutated in 22 of 34 patients. Twenty of 22 JAK2V617F-MPN (91%) maintained the mutation in blasts and GRA after leukemic switch, while in 2 of 22 patients the selected compartments lost the mutation. Surprisingly, we also found the first case of JAK2V617F-AML from a wild type (WT)-MPN. In contrast to the previous study, we conclude that JAK2V617F-MPN yields rarely (9%) a JAK2WT-AML and any JAK2-status modification/persistence involves always the entire BM during leukemic transformation.
2010
85
5
383
386
JAK2V617F mutation persists in blasts and mature cells of transformed JAK2V617F-positive-myeloproliferative neoplasia: A European Leukemia Net (ENL) study / Rinaldi, C. R.; Rinaldi, P.; Gemei, M.; Grimaldi, F.; Battipaglia, G.; Vecchio, L. D.; Martino, B.; Specchia, G.; Candoni, A.; Gugliotta, L.; Vannucchi, A. M.; Barbui, T.; Pane, F.. - In: AMERICAN JOURNAL OF HEMATOLOGY. - ISSN 0361-8609. - 85:5(2010), pp. 383-386. [10.1002/ajh.21687]
Rinaldi, C. R.; Rinaldi, P.; Gemei, M.; Grimaldi, F.; Battipaglia, G.; Vecchio, L. D.; Martino, B.; Specchia, G.; Candoni, A.; Gugliotta, L.; Vannucchi, A. M.; Barbui, T.; Pane, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1294112
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