Purpose of investigation: The aim of this study was to evaluate the ovarian function in women who received or not gonadotropin-releasing hormone (GnRH) analogue co-treatment compared to the control group that did not receive it. Materials and Methods: This study analyzed 124 patients affected by hematological diseases between 1998 and 2007. The data were analyzed using R (v 2.9.1). Results: In the women treated with GnRH analogue, the authors found 33% post-treatment secondary amenorrhea and 6% had a pregnancy post-treatment, while in the other group the prevalence were respectively 49% and 4% (p n.s.). Moreover, in multivariate analysis the authors found bone marrow transplantation to be a risk factor for secondary amenorrhea, while the association of chemotherapy with radiotherapy was a protective factor (p < 0.05). Finally, none of the considered factors were predictive of pregnancy achievement post-treatment. Conclusions: The authors found no statistical evidence to support that Gn-RH analogue treatment preserves ovarian follicular reserve during hematologic cancer treatment, but more evidence must be obtained.

Fertility in women survivors of hematological malignancies: What is the real role of GnRH analogue treatment? / Driul, L.; Londero, A. P.; Papadakis, C.; Candoni, A.; Bertozzi, S.; Fanin, R.; Marchesoni, D.. - In: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY. - ISSN 0390-6663. - 39:4(2012), pp. 504-508.

Fertility in women survivors of hematological malignancies: What is the real role of GnRH analogue treatment?

Candoni A.;
2012

Abstract

Purpose of investigation: The aim of this study was to evaluate the ovarian function in women who received or not gonadotropin-releasing hormone (GnRH) analogue co-treatment compared to the control group that did not receive it. Materials and Methods: This study analyzed 124 patients affected by hematological diseases between 1998 and 2007. The data were analyzed using R (v 2.9.1). Results: In the women treated with GnRH analogue, the authors found 33% post-treatment secondary amenorrhea and 6% had a pregnancy post-treatment, while in the other group the prevalence were respectively 49% and 4% (p n.s.). Moreover, in multivariate analysis the authors found bone marrow transplantation to be a risk factor for secondary amenorrhea, while the association of chemotherapy with radiotherapy was a protective factor (p < 0.05). Finally, none of the considered factors were predictive of pregnancy achievement post-treatment. Conclusions: The authors found no statistical evidence to support that Gn-RH analogue treatment preserves ovarian follicular reserve during hematologic cancer treatment, but more evidence must be obtained.
2012
39
4
504
508
Fertility in women survivors of hematological malignancies: What is the real role of GnRH analogue treatment? / Driul, L.; Londero, A. P.; Papadakis, C.; Candoni, A.; Bertozzi, S.; Fanin, R.; Marchesoni, D.. - In: CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY. - ISSN 0390-6663. - 39:4(2012), pp. 504-508.
Driul, L.; Londero, A. P.; Papadakis, C.; Candoni, A.; Bertozzi, S.; Fanin, R.; Marchesoni, D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1294080
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