Background: In patients with Mild Cognitive Impairment and normal biomarkers of amyloid-β deposition, prognostication remains challenging. Methods: We aimed at identifying clinical features, patterns of brain atrophy, and risk of subsequent conversion to dementia in a clinical cohort of consecutive patients with Mild Cognitive Impairment and normal CSF amyloid-β1-42 presenting to our Cognitive Neurology Clinic who were followed prospectively over an average of 25 months. We stratified them as Converters/Non-Converters to dementia based on clinical follow-up and compared baseline clinical features, CSF biomarkers, and pattern of atrophy on MRI data between groups. Results: Among 111 eligible patients (mean age 65,61 years; 56,8% were male), 41 patients developed a clinical diagnosis of dementia. Subjects with low baseline p/t-tau had twofold risk of future conversion compared to high p/t-tau ratio subjects (HR = 2.0, p = 0.026). When stratifying converters according to CSF p/t-tau ratio cut off value (0,17), those with values lower than the cut-off had significantly more MRI atrophy at baseline relative to Non-Converters in limbic structures. Conclusion: In Mild Cognitive Impairment patients with negative CSF amyloid biomarker, CSF p/t-tau ratio may be useful to identify those at greater risk of subsequent conversion, possibly because of TDP43-related underlying pathology.

Predictive value of phospho-tau/total-tau ratio in amyloid-negative Mild Cognitive Impairment / Tondelli, M.; Salemme, S.; Vinceti, G.; Bedin, R.; Trenti, T.; Molinari, M. A.; Chiari, A.; Zamboni, G.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 787:(2022), pp. N/A-N/A. [10.1016/j.neulet.2022.136811]

Predictive value of phospho-tau/total-tau ratio in amyloid-negative Mild Cognitive Impairment

Tondelli M.;Vinceti G.;Zamboni G.
2022

Abstract

Background: In patients with Mild Cognitive Impairment and normal biomarkers of amyloid-β deposition, prognostication remains challenging. Methods: We aimed at identifying clinical features, patterns of brain atrophy, and risk of subsequent conversion to dementia in a clinical cohort of consecutive patients with Mild Cognitive Impairment and normal CSF amyloid-β1-42 presenting to our Cognitive Neurology Clinic who were followed prospectively over an average of 25 months. We stratified them as Converters/Non-Converters to dementia based on clinical follow-up and compared baseline clinical features, CSF biomarkers, and pattern of atrophy on MRI data between groups. Results: Among 111 eligible patients (mean age 65,61 years; 56,8% were male), 41 patients developed a clinical diagnosis of dementia. Subjects with low baseline p/t-tau had twofold risk of future conversion compared to high p/t-tau ratio subjects (HR = 2.0, p = 0.026). When stratifying converters according to CSF p/t-tau ratio cut off value (0,17), those with values lower than the cut-off had significantly more MRI atrophy at baseline relative to Non-Converters in limbic structures. Conclusion: In Mild Cognitive Impairment patients with negative CSF amyloid biomarker, CSF p/t-tau ratio may be useful to identify those at greater risk of subsequent conversion, possibly because of TDP43-related underlying pathology.
787
N/A
N/A
Predictive value of phospho-tau/total-tau ratio in amyloid-negative Mild Cognitive Impairment / Tondelli, M.; Salemme, S.; Vinceti, G.; Bedin, R.; Trenti, T.; Molinari, M. A.; Chiari, A.; Zamboni, G.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - 787:(2022), pp. N/A-N/A. [10.1016/j.neulet.2022.136811]
Tondelli, M.; Salemme, S.; Vinceti, G.; Bedin, R.; Trenti, T.; Molinari, M. A.; Chiari, A.; Zamboni, G.
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S030439402200372X-main.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 2.77 MB
Formato Adobe PDF
2.77 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1288852
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact