Purpose: We aimed to evaluate the near-final height (nFHt) in a large cohort of pediatricpatients with growth hormone deficiency (GHD) and to elaborate a new predictive method of nFHt. Methods: We recruited GHD patients diagnosed between 1987 and 2014 and followed-up until nFHt. To predict the values of nFHt, each predictor was run in a univariable spline. Results: We enrolled 1051 patients. Pre-treatment height was −2.43 SDS, lower than parental height (THt) (−1.09 SDS, p < 0.001). The dose of recombinant human GH (rhGH) was 0.21mg/kg/week at start of treatment. nFHt was −1.08 SDS (height gain 1.27 SDS), higher than pre-treatment height (p < 0.001) and comparable to THt. 1.6% of the patients were shorter than −2 SDS from THt. The rhGH dose at nFHt was 0.19 mg/kg/week, lower than at the start (p < 0.001). The polynomial regression showed that nFHt was affected by gender, THt, age at puberty, height at puberty, age at the end of treatment (F = 325.37, p < 0.0001, R2 87.2%). Conclusion: This large national study shows that GHD children can reach their THt. The rhGH/kg/day dose significantly decreased from the start to the end of the treatment. Our model suggests the importance of a timely diagnosis, possibly before puberty, the beneficial effect of long-term treatment with rhGH, and the key-role of THt. Our prediction model has a very acceptable error compared to the majority of other published studies.

Isolated childhood growth hormone deficiency: a 30-year experience on final height and a new prediction model / Lonero, A.; Giotta, M.; Guerrini, G.; Calcaterra, V.; Galazzi, E.; Iughetti, L.; Cassio, A.; Wasniewska, G. M.; Mameli, C.; Tornese, G.; Salerno, M.; Cherubini, V.; Caruso Nicoletti, M.; Street, M. E.; Grandone, A.; Giacomozzi, C.; Faienza, M. F.; Guzzetti, C.; Bellone, S.; Parpagnoli, M.; Musolino, G.; Maggio, M. C.; Bozzola, M.; Trerotoli, P.; Del vecchio, M.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 45:9(2022), pp. 1709-1717. [10.1007/s40618-022-01808-4]

Isolated childhood growth hormone deficiency: a 30-year experience on final height and a new prediction model

Iughetti L.;Salerno M.;Del vecchio M.
2022

Abstract

Purpose: We aimed to evaluate the near-final height (nFHt) in a large cohort of pediatricpatients with growth hormone deficiency (GHD) and to elaborate a new predictive method of nFHt. Methods: We recruited GHD patients diagnosed between 1987 and 2014 and followed-up until nFHt. To predict the values of nFHt, each predictor was run in a univariable spline. Results: We enrolled 1051 patients. Pre-treatment height was −2.43 SDS, lower than parental height (THt) (−1.09 SDS, p < 0.001). The dose of recombinant human GH (rhGH) was 0.21mg/kg/week at start of treatment. nFHt was −1.08 SDS (height gain 1.27 SDS), higher than pre-treatment height (p < 0.001) and comparable to THt. 1.6% of the patients were shorter than −2 SDS from THt. The rhGH dose at nFHt was 0.19 mg/kg/week, lower than at the start (p < 0.001). The polynomial regression showed that nFHt was affected by gender, THt, age at puberty, height at puberty, age at the end of treatment (F = 325.37, p < 0.0001, R2 87.2%). Conclusion: This large national study shows that GHD children can reach their THt. The rhGH/kg/day dose significantly decreased from the start to the end of the treatment. Our model suggests the importance of a timely diagnosis, possibly before puberty, the beneficial effect of long-term treatment with rhGH, and the key-role of THt. Our prediction model has a very acceptable error compared to the majority of other published studies.
2022
45
9
1709
1717
Isolated childhood growth hormone deficiency: a 30-year experience on final height and a new prediction model / Lonero, A.; Giotta, M.; Guerrini, G.; Calcaterra, V.; Galazzi, E.; Iughetti, L.; Cassio, A.; Wasniewska, G. M.; Mameli, C.; Tornese, G.; Salerno, M.; Cherubini, V.; Caruso Nicoletti, M.; Street, M. E.; Grandone, A.; Giacomozzi, C.; Faienza, M. F.; Guzzetti, C.; Bellone, S.; Parpagnoli, M.; Musolino, G.; Maggio, M. C.; Bozzola, M.; Trerotoli, P.; Del vecchio, M.. - In: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION. - ISSN 0391-4097. - 45:9(2022), pp. 1709-1717. [10.1007/s40618-022-01808-4]
Lonero, A.; Giotta, M.; Guerrini, G.; Calcaterra, V.; Galazzi, E.; Iughetti, L.; Cassio, A.; Wasniewska, G. M.; Mameli, C.; Tornese, G.; Salerno, M.; ...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1288279
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