The impact of secondary infections (SI) on COVID-19 outcome in patients with hematological malignancies (HM) is scarcely documented. To evaluate incidence, clinical characteristics, and outcome of SI, we analyzed the microbiologically documented SI in a large multicenter cohort of adult HM patients with COVID-19. Among 1741 HM patients with COVID-19, 134 (7.7%) had 185 SI, with a 1-month cumulative incidence of 5%. Median time between COVID-19 diagnosis and SI was 16 days (IQR: 5–36). Acute myeloid leukemia (AML) and lymphoma/plasma cell neoplasms (PCN) were more frequent diagnoses in SI patients compared to patients without SI (AML: 14.9% vs. 7.1%; lymphoma/PCN 71.7% vs. 65.3%). Patients with SI were older (median age 70 vs. 66 years, p = 0.002), with more comorbidities (median Charlson Comorbidity Index 5 vs. 4, p < 0.001), higher frequency of critical COVID-19 (19.5% vs. 11.5%, p = 0.046), and more frequently not in complete remission (75% vs. 64.7% p = 0.024). Blood and bronchoalveolar lavage were the main sites of isolation for SI. Etiology of infections was bacterial in 80% (n = 148) of cases, mycotic in 9.7% (n = 18) and viral in 10.3% (n = 19); polymicrobial infections were observed in 24 patients (18%). Escherichia coli represented most of Gram-negative isolates (18.9%), while coagulase-negative Staphylococci were the most frequent among Gram-positive (14.2%). The 30-day mortality of patients with SI was higher when compared to patients without SI (69% vs. 15%, p < 0.001). The occurrence of SI worsened COVID-19 outcome in HM patients. Timely diagnosis and adequate management should be considered to improve their prognosis.

Secondary infections worsen the outcome of COVID-19 in patients with hematological malignancies: A report from the ITA-HEMA-COV / Zappasodi, P.; Cattaneo, C.; Valeria Ferretti, V.; Mina, R.; Jose Maria Ferreri, A.; Merli, F.; Oberti, M.; Krampera, M.; Romano, A.; Zerbi, C.; Ferrari, J.; Cavo, M.; Salvini, M.; Bertu, L.; Stefano Fracchiolla, N.; Marchesi, F.; Massaia, M.; Marasco, V.; Cairoli, R.; Maria Scattolin, A.; Maria Vannucchi, A.; Gambacorti-Passerini, C.; Musto, P.; Gherlinzoni, F.; Cuneo, A.; Pinto, A.; Trentin, L.; Bocchia, M.; Galimberti, S.; Coviello, E.; Chiara Tisi, M.; Morotti, A.; Falini, B.; Turrini, M.; Tafuri, A.; Billio, A.; Gentile, M.; Massimo Lemoli, R.; Venditti, A.; Giovanni Della Porta, M.; Lanza, F.; Rigacci, L.; Tosi, P.; Mohamed, S.; Corso, A.; Luppi, M.; Giuliani, N.; Busca, A.; Pagano, L.; Bruno, R.; Antonio Grossi, P.; Corradini, P.; Passamonti, F.; Arcaini, L.. - In: HEMATOLOGICAL ONCOLOGY. - ISSN 0278-0232. - (2022), pp. N/A-N/A. [10.1002/hon.3048]

Secondary infections worsen the outcome of COVID-19 in patients with hematological malignancies: A report from the ITA-HEMA-COV

Cattaneo C.;Ferrari J.;Cuneo A.;Pinto A.;Galimberti S.;Coviello E.;Luppi M.;Giuliani N.;Busca A.;Corradini P.;
2022-01-01

Abstract

The impact of secondary infections (SI) on COVID-19 outcome in patients with hematological malignancies (HM) is scarcely documented. To evaluate incidence, clinical characteristics, and outcome of SI, we analyzed the microbiologically documented SI in a large multicenter cohort of adult HM patients with COVID-19. Among 1741 HM patients with COVID-19, 134 (7.7%) had 185 SI, with a 1-month cumulative incidence of 5%. Median time between COVID-19 diagnosis and SI was 16 days (IQR: 5–36). Acute myeloid leukemia (AML) and lymphoma/plasma cell neoplasms (PCN) were more frequent diagnoses in SI patients compared to patients without SI (AML: 14.9% vs. 7.1%; lymphoma/PCN 71.7% vs. 65.3%). Patients with SI were older (median age 70 vs. 66 years, p = 0.002), with more comorbidities (median Charlson Comorbidity Index 5 vs. 4, p < 0.001), higher frequency of critical COVID-19 (19.5% vs. 11.5%, p = 0.046), and more frequently not in complete remission (75% vs. 64.7% p = 0.024). Blood and bronchoalveolar lavage were the main sites of isolation for SI. Etiology of infections was bacterial in 80% (n = 148) of cases, mycotic in 9.7% (n = 18) and viral in 10.3% (n = 19); polymicrobial infections were observed in 24 patients (18%). Escherichia coli represented most of Gram-negative isolates (18.9%), while coagulase-negative Staphylococci were the most frequent among Gram-positive (14.2%). The 30-day mortality of patients with SI was higher when compared to patients without SI (69% vs. 15%, p < 0.001). The occurrence of SI worsened COVID-19 outcome in HM patients. Timely diagnosis and adequate management should be considered to improve their prognosis.
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Secondary infections worsen the outcome of COVID-19 in patients with hematological malignancies: A report from the ITA-HEMA-COV / Zappasodi, P.; Cattaneo, C.; Valeria Ferretti, V.; Mina, R.; Jose Maria Ferreri, A.; Merli, F.; Oberti, M.; Krampera, M.; Romano, A.; Zerbi, C.; Ferrari, J.; Cavo, M.; Salvini, M.; Bertu, L.; Stefano Fracchiolla, N.; Marchesi, F.; Massaia, M.; Marasco, V.; Cairoli, R.; Maria Scattolin, A.; Maria Vannucchi, A.; Gambacorti-Passerini, C.; Musto, P.; Gherlinzoni, F.; Cuneo, A.; Pinto, A.; Trentin, L.; Bocchia, M.; Galimberti, S.; Coviello, E.; Chiara Tisi, M.; Morotti, A.; Falini, B.; Turrini, M.; Tafuri, A.; Billio, A.; Gentile, M.; Massimo Lemoli, R.; Venditti, A.; Giovanni Della Porta, M.; Lanza, F.; Rigacci, L.; Tosi, P.; Mohamed, S.; Corso, A.; Luppi, M.; Giuliani, N.; Busca, A.; Pagano, L.; Bruno, R.; Antonio Grossi, P.; Corradini, P.; Passamonti, F.; Arcaini, L.. - In: HEMATOLOGICAL ONCOLOGY. - ISSN 0278-0232. - (2022), pp. N/A-N/A. [10.1002/hon.3048]
Zappasodi, P.; Cattaneo, C.; Valeria Ferretti, V.; Mina, R.; Jose Maria Ferreri, A.; Merli, F.; Oberti, M.; Krampera, M.; Romano, A.; Zerbi, C.; Ferrari, J.; Cavo, M.; Salvini, M.; Bertu, L.; Stefano Fracchiolla, N.; Marchesi, F.; Massaia, M.; Marasco, V.; Cairoli, R.; Maria Scattolin, A.; Maria Vannucchi, A.; Gambacorti-Passerini, C.; Musto, P.; Gherlinzoni, F.; Cuneo, A.; Pinto, A.; Trentin, L.; Bocchia, M.; Galimberti, S.; Coviello, E.; Chiara Tisi, M.; Morotti, A.; Falini, B.; Turrini, M.; Tafuri, A.; Billio, A.; Gentile, M.; Massimo Lemoli, R.; Venditti, A.; Giovanni Della Porta, M.; Lanza, F.; Rigacci, L.; Tosi, P.; Mohamed, S.; Corso, A.; Luppi, M.; Giuliani, N.; Busca, A.; Pagano, L.; Bruno, R.; Antonio Grossi, P.; Corradini, P.; Passamonti, F.; Arcaini, L.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1288028
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