Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver etiologies and the condition of advanced chronic liver disease (cirrhosis) with related complications. To date, patients with liver disease, regardless of underlying etiology, have been shown to have reduced levels of vitamin D. There is also evidence of the predictive role of vitamin D values in complications and progression of advanced disease. However, specific indications of vitamin D supplementation are not conclusive concerning what is already recommended in the general population. Future studies should make an effort to unify and validate the role of vitamin D supplementation in chronic liver disease.

Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease / Federico, Ravaioli; Pivetti, Alessandra; DI MARCO, Lorenza; Christou, Chrysanthi; Frassanito, Gabriella; Pambianco, Martina; Sicuro, Chiara; Gualandi, Noemi; Guasconi, Tomas; Pecchini, Maddalena; Colecchia, Antonio. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:16(2022), pp. 9016-9037. [10.3390/ijms23169016]

Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease

Alessandra Pivetti;Lorenza Di Marco;Christou Chrysanthi;Gabriella Frassanito;Martina Pambianco;Chiara Sicuro;Noemi Gualandi;Tomas Guasconi;Maddalena Pecchini
;
Antonio Colecchia
2022

Abstract

Vitamin D is a crucial nutrient with many pleiotropic effects on health and various chronic diseases. The purpose of this review is to provide a detailed report on the pathophysiological mechanisms underlying vitamin D deficiency in patients with chronic liver disease, addressing the different liver etiologies and the condition of advanced chronic liver disease (cirrhosis) with related complications. To date, patients with liver disease, regardless of underlying etiology, have been shown to have reduced levels of vitamin D. There is also evidence of the predictive role of vitamin D values in complications and progression of advanced disease. However, specific indications of vitamin D supplementation are not conclusive concerning what is already recommended in the general population. Future studies should make an effort to unify and validate the role of vitamin D supplementation in chronic liver disease.
23
16
9016
9037
Role of Vitamin D in Liver Disease and Complications of Advanced Chronic Liver Disease / Federico, Ravaioli; Pivetti, Alessandra; DI MARCO, Lorenza; Christou, Chrysanthi; Frassanito, Gabriella; Pambianco, Martina; Sicuro, Chiara; Gualandi, Noemi; Guasconi, Tomas; Pecchini, Maddalena; Colecchia, Antonio. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:16(2022), pp. 9016-9037. [10.3390/ijms23169016]
Federico, Ravaioli; Pivetti, Alessandra; DI MARCO, Lorenza; Christou, Chrysanthi; Frassanito, Gabriella; Pambianco, Martina; Sicuro, Chiara; Gualandi, Noemi; Guasconi, Tomas; Pecchini, Maddalena; Colecchia, Antonio
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