The effects of the exposure of mitogen-stimulated human lymphocytes from aged subjects to low-frequency pulsed electromagnetic fields (PEMFs) were studied by measuring the production of interleukin-2 (IL-2) and the expression of IL-2 receptor. PEMF-exposed cultures that presented increased [3H]thymidine incorporation showed lower amounts of IL-2 in their supernatants, but higher percentages of IL-2 receptor-positive cells and of T-activated lymphocytes. Taken together, these data suggest that PEMFs were able to modulate mitogen-induced lymphocyte proliferation by provoking an increase in utilization of IL-2, most likely acting on the expression of its receptor on the plasma membrane. © 1989.
Extremely low frequency pulsed electromagnetic fields increase interleukin-2 (IL-2) utilization and IL-2 receptor expression in mitogen-stimulated human lymphocytes from old subjects / Cossarizza, A.; Monti, D.; Bersani, F.; Paganelli, R.; Montagnani, G.; Cadossi, R.; Cantini, M.; Franceschi, C.. - In: FEBS LETTERS. - ISSN 0014-5793. - 248:1-2(1989), pp. 141-144. [10.1016/0014-5793(89)80449-1]