The influence of hereditary and environmental factors in the regulation of the serum levels of IgM, IgG and IgA and of the complement components C3, C4 and factor B has been studied. For this purpose, sera from 9 monozygotic twin pairs, from 10 dizygotic twin pairs and from two control groups were analyzed. The first control group consisted of three healthy donors analyzed once a week for three weeks, as a genetic identity experimental control, while the second one was constituted by nine subjects randomly selected as a genetic heterogeneity control. The results indicate that the serum proteins with immunological functions can be subdivided into three groups. The first, represented by IgM and IgG, appears to be under strict genetic control; the second, represented by IgA and C3, appears to be influenced either by genetic or environmental factors; the third one, including C4 and factor B, is strongly influenced by environmental factors.
Genetic and environmental influences on serum levels of immunoglobulins and complement components in monozygotic and dizygotic twins / Di Franco, P.; Brai, M.; Misiano, G.; Piazza, A. M.; Giorgi, G.; Cossarizza, A.; Franceschi, C.. - In: JOURNAL OF CLINICAL & LABORATORY IMMUNOLOGY. - ISSN 0141-2760. - 27:1(1988), pp. 5-10.
Genetic and environmental influences on serum levels of immunoglobulins and complement components in monozygotic and dizygotic twins
Cossarizza A.;Franceschi C.
1988
Abstract
The influence of hereditary and environmental factors in the regulation of the serum levels of IgM, IgG and IgA and of the complement components C3, C4 and factor B has been studied. For this purpose, sera from 9 monozygotic twin pairs, from 10 dizygotic twin pairs and from two control groups were analyzed. The first control group consisted of three healthy donors analyzed once a week for three weeks, as a genetic identity experimental control, while the second one was constituted by nine subjects randomly selected as a genetic heterogeneity control. The results indicate that the serum proteins with immunological functions can be subdivided into three groups. The first, represented by IgM and IgG, appears to be under strict genetic control; the second, represented by IgA and C3, appears to be influenced either by genetic or environmental factors; the third one, including C4 and factor B, is strongly influenced by environmental factors.Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris