In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.

QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies / Whiting, Pf; Rutjes, A; Westwood, Me; Mallett, S; Deeks, Jj; Reitsma, Jb; Leeflang, Mm; Sterne, Ja; Bossuyt, Pm; QUADAS-2, Group. - In: ANNALS OF INTERNAL MEDICINE. - ISSN 0003-4819. - 155:8(2011), pp. 529-536. [10.7326/0003-4819-155-8-201110180-00009]

QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

Rutjes A;
2011

Abstract

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
2011
155
8
529
536
QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies / Whiting, Pf; Rutjes, A; Westwood, Me; Mallett, S; Deeks, Jj; Reitsma, Jb; Leeflang, Mm; Sterne, Ja; Bossuyt, Pm; QUADAS-2, Group. - In: ANNALS OF INTERNAL MEDICINE. - ISSN 0003-4819. - 155:8(2011), pp. 529-536. [10.7326/0003-4819-155-8-201110180-00009]
Whiting, Pf; Rutjes, A; Westwood, Me; Mallett, S; Deeks, Jj; Reitsma, Jb; Leeflang, Mm; Sterne, Ja; Bossuyt, Pm; QUADAS-2, Group
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1286666
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